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10.1016/j.jns.2014.12.015 http://scihub22266oqcxt.onion/10.1016/j.jns.2014.12.015 C6044427!6044427!25577314     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neurol+Sci 2015 ; 348 (1-2): 241-4 Nephropedia Template TP {{tp|p=25577314|t=2015. Collagen Q ? A potential target for autoantibodies in myasthenia gravis |pdf=|usr=}}{{25577314}} gab.com Text Collagen Q A potential target for autoantibodies in myasthenia gravis JO: J Neurol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25577314 #FOAvip Myasthenia gravis (MG) is an autoimmune disorder caused by autoantibodies targeting proteins expressed at the neuromuscular junction (NMJ). In most cases the targets are acetylcholine receptor (AChR), muscle-specific tyrosine kinase (MuSK), or occasionally low-density lipoprotein receptor-related protein 4 (LRP4), but there is still a group of patients, often called seronegative MG (SNMG), with unknown antibody targets. One potential target is collagen Q (COLQ), which is restricted to the NMJ and is crucial for anchoring the NMJ-specific form of acetylcholinesterase (AChE). 415 serum samples with a clinical diagnosis of MG and 43 control samples were screened for the presence of COLQ autoantibodies using a cell-based assay (CBA) with HEK293 cells overexpressing COLQ at the cell surface. COLQ antibodies were detected in 12/415 MG sera and in one/43 control samples. Five of the COLQ-Ab + individuals were also positive for AChR-Abs and 2 for MuSK-Abs. Although the COLQ antibodies were only present at low frequency, and did not differ significantly from the small control cohort, further studies could address whether they modify the clinical presentation or the benefits of anti-cholinesterase therapy. Twit Text FOAVip Collagen Q A potential target for autoantibodies in myasthenia gravis ????J Neurol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25577314 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25577314 #FOAvip English Wikipedia <ref>{{Cite pmid|25577314}}</ref> Collagen Q ? A potential target for autoantibodies in myasthenia gravis #MMPMID25577314 Zoltowska Katarzyna M; Belaya K; Leite M; Patrick W; Vincent A; Beeson D J Neurol Sci 2015[Jan]; 348 (1-2): 241-4 PMID25577314show ga Myasthenia gravis (MG) is an autoimmune disorder caused by autoantibodies targeting proteins expressed at the neuromuscular junction (NMJ). In most cases the targets are acetylcholine receptor (AChR), muscle-specific tyrosine kinase (MuSK), or occasionally low-density lipoprotein receptor-related protein 4 (LRP4), but there is still a group of patients, often called seronegative MG (SNMG), with unknown antibody targets. One potential target is collagen Q (COLQ), which is restricted to the NMJ and is crucial for anchoring the NMJ-specific form of acetylcholinesterase (AChE). 415 serum samples with a clinical diagnosis of MG and 43 control samples were screened for the presence of COLQ autoantibodies using a cell-based assay (CBA) with HEK293 cells overexpressing COLQ at the cell surface. COLQ antibodies were detected in 12/415 MG sera and in one/43 control samples. Five of the COLQ-Ab + individuals were also positive for AChR-Abs and 2 for MuSK-Abs. Although the COLQ antibodies were only present at low frequency, and did not differ significantly from the small control cohort, further studies could address whether they modify the clinical presentation or the benefits of anti-cholinesterase therapy. äCollagen Q ? A potential target for autoantibodies in myasthenia gravi(epmc).pdf DeepDyve Pubget Overpricing