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10.18632/oncotarget.25624 http://scihub22266oqcxt.onion/10.18632/oncotarget.25624 C6044382!6044382!30018738     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2018 ; 9 (49): 29097-111 Nephropedia Template TP {{tp|p=30018738|t=2018. InDePTH: detection of hub genes for developing gene expression networks under anticancer drug treatment |pdf=|usr=}}{{30018738}} gab.com Text InDePTH: detection of hub genes for developing gene expression networks under anticancer drug treatment JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=30018738 #FOAvip It has been difficult to elucidate the structure of gene regulatory networks under anticancer drug treatment. Here, we developed an algorithm to highlight the hub genes that play a major role in creating the upstream and downstream relationships within a given set of differentially expressed genes. The directionality of the relationships between genes was defined using information from comprehensive collections of transcriptome profiles after gene knockdown and overexpression. As expected, among the drug-perturbed genes, our algorithm tended to derive plausible hub genes, such as transcription factors. Our validation experiments successfully showed the anticipated activity of certain hub gene in establishing the gene regulatory network that was associated with cell growth inhibition. Notably, giving such top priority to the hub gene was not achieved by ranking fold change in expression and by the conventional gene set enrichment analysis of drug-induced transcriptome data. Thus, our data-driven approach can facilitate to understand drug-induced gene regulatory networks for finding potential functional genes. Twit Text FOAVip InDePTH: detection of hub genes for developing gene expression networks under anticancer drug treatment ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=30018738 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30018738 #FOAvip English Wikipedia <ref>{{Cite pmid|30018738}}</ref> InDePTH: detection of hub genes for developing gene expression networks under anticancer drug treatment #MMPMID30018738 Koido M; Tani Y; Tsukahara S; Okamoto Y; Tomida A Oncotarget 2018[Jun]; 9 (49): 29097-111 PMID30018738show ga It has been difficult to elucidate the structure of gene regulatory networks under anticancer drug treatment. Here, we developed an algorithm to highlight the hub genes that play a major role in creating the upstream and downstream relationships within a given set of differentially expressed genes. The directionality of the relationships between genes was defined using information from comprehensive collections of transcriptome profiles after gene knockdown and overexpression. As expected, among the drug-perturbed genes, our algorithm tended to derive plausible hub genes, such as transcription factors. Our validation experiments successfully showed the anticipated activity of certain hub gene in establishing the gene regulatory network that was associated with cell growth inhibition. Notably, giving such top priority to the hub gene was not achieved by ranking fold change in expression and by the conventional gene set enrichment analysis of drug-induced transcriptome data. Thus, our data-driven approach can facilitate to understand drug-induced gene regulatory networks for finding potential functional genes. äInDePTH: detection of hub genes for developing gene expression network(epmc).pdf DeepDyve Pubget Overpricing