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2018 ; 11
(ä): 3959-3968
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SIRT4 acts as a tumor suppressor in gastric cancer by inhibiting cell
proliferation, migration, and invasion
#MMPMID30022839
Sun H
; Huang D
; Liu G
; Jian F
; Zhu J
; Zhang L
Onco Targets Ther
2018[]; 11
(ä): 3959-3968
PMID30022839
show ga
BACKGROUND: Previous study has proven that SIRT4 is downregulated in gastric
cancer (GC), but the role of SIRT4 has not been clearly understood. The aim of
our work was to explore in detail the function and mechanism of SIRT4 in GC.
METHODS: A total of 86 pairs of GC tumor tissues and adjacent normal tissues were
collected, and quantitative real-time polymerase chain reaction and Western
blotting analyses were used to determine the expression of SIRT4. RESULTS: Our
study revealed that the expression of SIRT4 was downregulated in GC tissues and
cells. In addition, the low expression of SIRT4 was negatively correlated with
tumor size, pathological grade, and lymph node metastasis, which predicted a poor
prognosis. Multiple functional experiments, including Cell Counting Kit-8 assay
as well as colony formation assay, demonstrated SIRT4 suppressed cell
proliferation. Moreover, we found epithelial-mesenchymal transition was regulated
by SIRT4, thereby regulating cell migration and invasion. CONCLUSION: Overall,
our findings show that SIRT4 serves as a tumor suppressor in GC and might act as
a novel biomarker and a therapeutic target of GC.