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10.1186/s12872-018-0885-2 http://scihub22266oqcxt.onion/10.1186/s12872-018-0885-2 C6044074!6044074 !30005636     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30005636 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       BMC+Cardiovasc+Disord 2018 ; 18 (1 ): 145 Nephropedia Template TP {{tp|p=30005636 |t=2018. Defining myocardial fibrosis in haemodialysis patients with non-contrast cardiac magnetic resonance |pdf=|usr=}}{{30005636 }} gab.com Text Defining myocardial fibrosis in haemodialysis patients with non-contrast cardiac magnetic resonance JO: BMC Cardiovasc Disord http://www.kidney.de/pget.php?&tw=1&pmid=30005636 #FOAvip BACKGROUND: Extent of myocardial fibrosis (MF) determined using late gadolinium enhanced (LGE) predicts outcomes, but gadolinium is contraindicated in advanced renal disease. We assessed the ability of native T1-mapping to identify and quantify MF in aortic stenosis patients (AS) as a model for use in haemodialysis patients. METHODS: We compared the ability to identify areas of replacement-MF using native T1-mapping to LGE in 25 AS patients at 3 T. We assessed agreement between extent of MF defined by LGE full-width-half-maximum (FWHM) and the LGE 3-standard-deviations (3SD) in AS patients and nine T1 thresholding-techniques, with thresholds set 2-to-9 standard-deviations above normal-range (1083?±?33 ms). A further technique was tested that set an individual T1-threshold for each patient (T11SD). The technique that agreed most strongly with FWHM or 3SD in AS patients was used to compare extent of MF between AS (n?=?25) and haemodialysis patients (n?=?25). RESULTS: Twenty-six areas of enhancement were identified on LGE images, with 25 corresponding areas of discretely increased native T1 signal identified on T1 maps. Global T1 was higher in haemodialysis than AS patients (1279 ms?±?5.8 vs 1143 ms?±?12.49, P?<?0.01). No signal-threshold technique derived from standard-deviations above normal-range associated with FWHM or 3SD. T11SD correlated with FWHM in AS patients (r?=?0.55) with moderate agreement (ICC?=?0.64), (but not with 3SD). Extent of MF defined by T11SD was higher in haemodialysis vs AS patients (21.92%?±?1 vs 18.24%?±?1.4, P?=?0.038), as was T1 in regions-of-interest defined as scar (1390?±?8.7 vs 1276 ms?±?20.5, P?<?0.01). There was no difference in the relative difference between remote myocardium and regions defined as scar, between groups (111.4 ms?±?7.6 vs 133.2 ms?±?17.5, P?=?0.26). CONCLUSIONS: Areas of MF are identifiable on native T1 maps, but absolute thresholds to define extent of MF could not be determined. Histological studies are needed to assess the ability of native-T1 signal-thresholding techniques to define extent of MF in haemodialysis patients. Data is taken from the PRIMID-AS (NCT01658345) and CYCLE-HD studies (ISRCTN11299707). Twit Text FOAVip Defining myocardial fibrosis in haemodialysis patients with non-contrast cardiac magnetic resonance ????BMC Cardiovasc Disord http://www.kidney.de/pget.php?&tw=1&pmid=30005636 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30005636 #FOAvip English Wikipedia <ref>{{Cite pmid|30005636 }}</ref> Defining myocardial fibrosis in haemodialysis patients with non-contrast cardiac magnetic resonance #MMPMID30005636 Graham-Brown MP ; Singh AS ; Gulsin GS ; Levelt E ; Arnold JA ; Stensel DJ ; Burton JO ; McCann GP BMC Cardiovasc Disord 2018[Jul]; 18 (1 ): 145 PMID30005636 show ga BACKGROUND: Extent of myocardial fibrosis (MF) determined using late gadolinium enhanced (LGE) predicts outcomes, but gadolinium is contraindicated in advanced renal disease. We assessed the ability of native T1-mapping to identify and quantify MF in aortic stenosis patients (AS) as a model for use in haemodialysis patients. METHODS: We compared the ability to identify areas of replacement-MF using native T1-mapping to LGE in 25 AS patients at 3 T. We assessed agreement between extent of MF defined by LGE full-width-half-maximum (FWHM) and the LGE 3-standard-deviations (3SD) in AS patients and nine T1 thresholding-techniques, with thresholds set 2-to-9 standard-deviations above normal-range (1083?±?33 ms). A further technique was tested that set an individual T1-threshold for each patient (T11SD). The technique that agreed most strongly with FWHM or 3SD in AS patients was used to compare extent of MF between AS (n?=?25) and haemodialysis patients (n?=?25). RESULTS: Twenty-six areas of enhancement were identified on LGE images, with 25 corresponding areas of discretely increased native T1 signal identified on T1 maps. Global T1 was higher in haemodialysis than AS patients (1279 ms?±?5.8 vs 1143 ms?±?12.49, P? |*Magnetic Resonance Imaging/adverse effects [MESH] |*Renal Dialysis/adverse effects [MESH] |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Aortic Valve Stenosis/*complications/diagnostic imaging/pathology [MESH] |Cardiomyopathies/*diagnostic imaging/etiology/pathology [MESH] |Contrast Media/administration & dosage/adverse effects [MESH] |Female [MESH] |Fibrosis [MESH] |Humans [MESH] |Kidney Failure, Chronic/complications/diagnosis/*therapy [MESH] |Male [MESH] |Middle Aged [MESH] |Myocardium/*pathology [MESH] |Organometallic Compounds/administration & dosage/adverse effects [MESH] |Predictive Value of Tests [MESH] |Risk Factors [MESH]Defining myocardial fibrosis in haemodialysis patients with non-contra(epmc).pdf DeepDyve Pubget Overpricing