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10.1177/1179573518787469 http://scihub22266oqcxt.onion/10.1177/1179573518787469 C6043941!6043941!30013417     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cent+Nerv+Syst+Dis 2018 ; 10 (ä): ä Nephropedia Template TP {{tp|p=30013417|t=2018. Unraveling of Central Nervous System Disease Mechanisms Using CRISPR Genome Manipulation |pdf=|usr=}}{{30013417}} gab.com Text Unraveling of Central Nervous System Disease Mechanisms Using CRISPR Genome Manipulation JO: J Cent Nerv Syst Dis http://www.kidney.de/pget.php?&tw=1&pmid=30013417 #FOAvip The complex structure and highly variable gene expression profile of the brain makes it among the most challenging fields to study in both basic and translational biological research. Most of the brain diseases are multifactorial and despite the rapidly increasing genomic data, molecular pathways and causal links between genes and central nervous system (CNS) diseases are largely unknown. The advent of an easy and flexible CRISPR-Cas genome editing technology has rapidly revolutionized the field of functional genomics and opened unprecedented possibilities to dissect the mechanisms of CNS disease. CRISPR-Cas allows a plenitude of applications for both gene-focused and genome-wide approaches, ranging from original ?gene scissors? making permanent modifications in the genome to the regulation of gene expression and epigenetics. CRISPR technology provides a unique opportunity to establish new cellular and animal models of CNS diseases and holds potential for breakthroughs in the CNS research and drug development. Twit Text FOAVip Unraveling of Central Nervous System Disease Mechanisms Using CRISPR Genome Manipulation ????J Cent Nerv Syst Dis http://www.kidney.de/pget.php?&tw=1&pmid=30013417 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30013417 #FOAvip English Wikipedia <ref>{{Cite pmid|30013417}}</ref> Unraveling of Central Nervous System Disease Mechanisms Using CRISPR Genome Manipulation #MMPMID30013417 Vesikansa A J Cent Nerv Syst Dis 2018[]; 10 (ä): ä PMID30013417show ga The complex structure and highly variable gene expression profile of the brain makes it among the most challenging fields to study in both basic and translational biological research. Most of the brain diseases are multifactorial and despite the rapidly increasing genomic data, molecular pathways and causal links between genes and central nervous system (CNS) diseases are largely unknown. The advent of an easy and flexible CRISPR-Cas genome editing technology has rapidly revolutionized the field of functional genomics and opened unprecedented possibilities to dissect the mechanisms of CNS disease. CRISPR-Cas allows a plenitude of applications for both gene-focused and genome-wide approaches, ranging from original ?gene scissors? making permanent modifications in the genome to the regulation of gene expression and epigenetics. CRISPR technology provides a unique opportunity to establish new cellular and animal models of CNS diseases and holds potential for breakthroughs in the CNS research and drug development. äUnraveling of Central Nervous System Disease Mechanisms Using CRISPR G(epmc).pdf DeepDyve Pubget Overpricing