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10.1002/brb3.1012 http://scihub22266oqcxt.onion/10.1002/brb3.1012 C6043713!6043713!29856136     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brain+Behav 2018 ; 8 (7): ä Nephropedia Template TP {{tp|p=29856136|t=2018. Prodromal headache in anti?NMDAR encephalitis: An epiphenomenon of NMDAR autoimmunity |pdf=|usr=}}{{29856136}} gab.com Text Prodromal headache in anti NMDAR encephalitis: An epiphenomenon of NMDAR autoimmunity JO: Brain Behav http://www.kidney.de/pget.php?&tw=1&pmid=29856136 #FOAvip Objective: To investigate the nature of prodromal headache in anti?NMDA receptor (NMDAR) encephalitis. Methods: Retrospective review of the clinical information of 39 patients with anti?NMDAR encephalitis admitted between January 1999 and September 2017. Five patients with an atypical presentation were excluded. Thus, in 34 patients (median 27 years [range, 12?47 years]; 28 [82%] female), the clinical features were compared between patients who initially reported headache and those who did not report. Results: Twenty?two patients (65%) reported headache either transiently (n = 5) or continuously (n = 17). Encephalitic symptoms (psychobehavioral memory alterations, seizure, dyskinesias, or altered level of consciousness) developed in 20 patients with median 5.5 days (range, 1?29 days) after headache onset. In one patient, NMDAR antibodies were detected in CSF 3 days after headache onset. Patients with headache had more frequently fever (14/22 [64%] vs. 2/12 [17%] p = 0.013) and higher CSF pleocytosis (median white blood cells 79/?l [range, 6?311/?l] vs. 30/?l [range, 2?69/?l], p = 0.035) than those without headache, but there was no difference in gender, age at onset, seizure, migraine, CSF oligoclonal band detection, elevated IgG index, tumor association, or brain MRI abnormalities between them. Conclusions: Headache often developed with fever and pleocytosis, but it was rapidly replaced by psychiatric symptoms. Based on current knowledge on the antibody?mediated mechanisms that cause a decrease of synaptic NMDAR through crosslinking and internalization leading to a state mimicking ?dissociative anesthesia,? we speculated that prodromal headache is not likely caused by direct effect of the autoantibodies but rather meningeal inflammation (noninfectious aseptic meningitis) that occurs in parallel to intrathecal antibody synthesis as an epiphenomenon of NMDAR autoimmunity. Psychobehavioral alterations following headache is an important clue to the diagnosis. Twit Text FOAVip Prodromal headache in anti NMDAR encephalitis: An epiphenomenon of NMDAR autoimmunity ????Brain Behav http://www.kidney.de/pget.php?&tw=1&pmid=29856136 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29856136 #FOAvip English Wikipedia <ref>{{Cite pmid|29856136}}</ref> Prodromal headache in anti?NMDAR encephalitis: An epiphenomenon of NMDAR autoimmunity #MMPMID29856136 Tominaga N; Kanazawa N; Kaneko A; Kaneko J; Kitamura E; Nakagawa H; Nishiyama K; Iizuka T Brain Behav 2018[Jul]; 8 (7): ä PMID29856136show ga Objective: To investigate the nature of prodromal headache in anti?NMDA receptor (NMDAR) encephalitis. Methods: Retrospective review of the clinical information of 39 patients with anti?NMDAR encephalitis admitted between January 1999 and September 2017. Five patients with an atypical presentation were excluded. Thus, in 34 patients (median 27 years [range, 12?47 years]; 28 [82%] female), the clinical features were compared between patients who initially reported headache and those who did not report. Results: Twenty?two patients (65%) reported headache either transiently (n = 5) or continuously (n = 17). Encephalitic symptoms (psychobehavioral memory alterations, seizure, dyskinesias, or altered level of consciousness) developed in 20 patients with median 5.5 days (range, 1?29 days) after headache onset. In one patient, NMDAR antibodies were detected in CSF 3 days after headache onset. Patients with headache had more frequently fever (14/22 [64%] vs. 2/12 [17%] p = 0.013) and higher CSF pleocytosis (median white blood cells 79/?l [range, 6?311/?l] vs. 30/?l [range, 2?69/?l], p = 0.035) than those without headache, but there was no difference in gender, age at onset, seizure, migraine, CSF oligoclonal band detection, elevated IgG index, tumor association, or brain MRI abnormalities between them. Conclusions: Headache often developed with fever and pleocytosis, but it was rapidly replaced by psychiatric symptoms. Based on current knowledge on the antibody?mediated mechanisms that cause a decrease of synaptic NMDAR through crosslinking and internalization leading to a state mimicking ?dissociative anesthesia,? we speculated that prodromal headache is not likely caused by direct effect of the autoantibodies but rather meningeal inflammation (noninfectious aseptic meningitis) that occurs in parallel to intrathecal antibody synthesis as an epiphenomenon of NMDAR autoimmunity. Psychobehavioral alterations following headache is an important clue to the diagnosis. äProdromal headache in anti?NMDAR encephalitis: An epiphenomenon of NMD(epmc).pdf DeepDyve Pubget Overpricing