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2018 ; 8
(7
): e00996
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Hippocampal involvement in nonpathological déjà vu: Subfield vulnerability rather
than temporal lobe epilepsy equivalent
#MMPMID29873197
Pe?lová E
; Mare?ek R
; Shaw DJ
; Ka?párek T
; Pail M
; Brázdil M
Brain Behav
2018[Jul]; 8
(7
): e00996
PMID29873197
show ga
INTRODUCTION: Morphological correlates of nonpathological déjà vu (DV) have been
identified recently within the human brain. Significantly reduced gray matter
volume (GMV) within a set of cortical and subcortical regions reported in
subjects experiencing DV seems to mirror the distribution of GMV reduction in
mesial temporal lobe epilepsy (MTLE) patients but vary in terms of the
hippocampus. Another condition associated with hippocampal GMV reduction and DV
alike disturbance in memory processing is schizophrenia (SCH). Here, we tested
the hypothesis that hippocampal involvement in nonpathological DV resembles more
closely the pattern of GMV decrease observed in MTLE compared with that occurring
in SCH. METHODS: Using automated segmentation of the MRI data we compared the
medians of GMV within 12 specific hippocampal subfields in healthy individuals
that do (DV+; N = 87) and do not report déjà vu experience (DV-; N = 26), and
patients with MTLE (N = 47) and SCH (N = 29). By Pearson correlation, we then
evaluated the similarity of MTLE and SCH groups to DV+ group with respect to
spatial distribution of GMV deviation from DV- group. RESULTS: Significant GMV
decrease was found in MTLE group in most of the subfields. There were just trends
in the hippocampal GMV decrease found in DV+ or SCH groups. Concerning the
spatial distribution of GMV decrease, we revealed statistically significant
correlation for the left hippocampus for SCH vs DV+. Otherwise there was no
statistically significant correlation. CONCLUSIONS: Our findings reveal
structural features of hippocampal involvement in nonpathological DV, MTLE, and
SCH. Despite our expectations, the pattern of GMV reduction in the DV+ relative
to the DV- group does not resemble the pattern observed in MTLE any more than
that observed in SCH. The highly similar patterns of the three clinical groups
rather suggest an increased vulnerability of certain hippocampal subfields;
namely, Cornu Ammonis (CA)4, CA3, dentate gyrus granular cell layer (GC-DG),
hippocampal-amygdaloid transition area (HATA) and subiculum.
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