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2018 ; 9
(ä): 1559
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Neutrophil Extracellular Traps Formation and Aggregation Orchestrate Induction
and Resolution of Sterile Crystal-Mediated Inflammation
#MMPMID30034398
Li Y
; Cao X
; Liu Y
; Zhao Y
; Herrmann M
Front Immunol
2018[]; 9
(ä): 1559
PMID30034398
show ga
The formation of neutrophil extracellular traps (NETs) to immobilize pathogens
represents a novel antimicrobial strategy of the immune system. The microcrystals
related to human diseases are classified into endogenous microcrystals, including
monosodium urate (MSU), calcium pyrophosphate dihydrate, calcium carbonate,
calcium phosphate, calcium oxalate, cholesterol, and exogenous material like
crystals from silica. Although microcrystals possess distinct compositions and
shapes, they have a common characteristic: they stimulate neutrophils to release
NETs. In low and high densities, neutrophils form NETs and aggregated NETs
(aggNETs) that reportedly orchestrate the initiation and resolution of sterile
crystal-mediated inflammation, respectively. Here, we summarize the different
roles of NETs and aggNETs stimulated by the crystals mentioned above in related
inflammatory reactions. The NETosis-derived products may represent a potential
therapeutic target in crystal-mediated diseases.