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2018 ; 8
(1
): 10510
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gab.com Text
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Relationship between Systemic Vascular Characteristics and Retinal Nerve Fiber
Layer Loss in Patients with Type 2 Diabetes
#MMPMID30002461
Jeon SJ
; Park HL
; Lee JH
; Park CK
Sci Rep
2018[Jul]; 8
(1
): 10510
PMID30002461
show ga
Retinal nerve fiber layer (RNFL) loss in diabetic patients is especially common
regardless of diabetic retinopathy (DR). The correlations between nonglaucomatous
RNFL loss and systemic characteristics in diabetic patients have aroused
interests in many aspects. 167 subjects with type 2 diabetes who underwent
evaluation for arterial stiffness and cardiovascular autonomic function using
heart rate variability (HRV) were included in this study. Arterial stiffness was
measured using cardio-ankle vascular index (CAVI) and ankle-brachial index (ABI).
Multivariate regression analysis was performed to determine factors influencing
the presence of RNFL loss according to age. Factors determining the superior
location of diabetic RNFL loss were also investigated. CAVI were worse in
patients with RNFL loss, especially in those with old age (?50?yrs) (p?=?0.037).
Influential factor of RNFL defect in old group was ABI (p?=?0.007). However, in
young group (<50?yrs), HRV parameter (low-frequency/high-frequency ratio)
determined the presence of RNFL loss (p?=?0.040). Significant determinants of
superior RNFL defect in old subjects were CAVI and ABI (p?=?0.032 and p?=?0.024).
For young diabetic patients, autonomic dysfunction may have relationship with
RNFL loss, but as patients get older, arterial stiffness could aggravate vascular
autoregulation and diabetic RNFL loss. RNFL loss in diabetes may be correlated
with systemic vascular conditions.
|Adult
[MESH]
|Age Factors
[MESH]
|Aged
[MESH]
|Ankle Brachial Index
[MESH]
|Diabetes Mellitus, Type 2/*complications/physiopathology
[MESH]