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10.1371/journal.pgen.1007485 http://scihub22266oqcxt.onion/10.1371/journal.pgen.1007485 C6042690!6042690!30001316     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Genet 2018 ; 14 (7): ä Nephropedia Template TP {{tp|p=30001316|t=2018. Ikaros cooperates with Notch activation and antagonizes TGF? signaling to promote pDC development |pdf=|usr=}}{{30001316}} gab.com Text Ikaros cooperates with Notch activation and antagonizes TGF signaling to promote pDC development JO: PLoS Genet http://www.kidney.de/pget.php?&tw=1&pmid=30001316 #FOAvip Plasmacytoid and conventional dendritic cells (pDCs and cDCs) arise from monocyte and dendritic progenitors (MDPs) and common dendritic progenitors (CDPs) through gene expression changes that remain partially understood. Here we show that the Ikaros transcription factor is required for DC development at multiple stages. Ikaros cooperates with Notch pathway activation to maintain the homeostasis of MDPs and CDPs. Ikaros then antagonizes TGF? function to promote pDC differentiation from CDPs. Strikingly, Ikaros-deficient CDPs and pDCs express a cDC-like transcriptional signature that is correlated with TGF? activation, suggesting that Ikaros is an upstream negative regulator of the TGF? pathway and a repressor of cDC-lineage genes in pDCs. Almost all of these phenotypes can be rescued by short-term in vitro treatment with ?-secretase inhibitors, which affects both TGF?-dependent and -independent pathways, but is Notch-independent. We conclude that Ikaros is a crucial differentiation factor in early dendritic progenitors that is required for pDC identity. Twit Text FOAVip Ikaros cooperates with Notch activation and antagonizes TGF signaling to promote pDC development ????PLoS Genet http://www.kidney.de/pget.php?&tw=1&pmid=30001316 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30001316 #FOAvip English Wikipedia <ref>{{Cite pmid|30001316}}</ref> Ikaros cooperates with Notch activation and antagonizes TGF? signaling to promote pDC development #MMPMID30001316 Mastio J; Simand C; Cova G; Kastner P; Chan S; Kirstetter P PLoS Genet 2018[Jul]; 14 (7): ä PMID30001316show ga Plasmacytoid and conventional dendritic cells (pDCs and cDCs) arise from monocyte and dendritic progenitors (MDPs) and common dendritic progenitors (CDPs) through gene expression changes that remain partially understood. Here we show that the Ikaros transcription factor is required for DC development at multiple stages. Ikaros cooperates with Notch pathway activation to maintain the homeostasis of MDPs and CDPs. Ikaros then antagonizes TGF? function to promote pDC differentiation from CDPs. Strikingly, Ikaros-deficient CDPs and pDCs express a cDC-like transcriptional signature that is correlated with TGF? activation, suggesting that Ikaros is an upstream negative regulator of the TGF? pathway and a repressor of cDC-lineage genes in pDCs. Almost all of these phenotypes can be rescued by short-term in vitro treatment with ?-secretase inhibitors, which affects both TGF?-dependent and -independent pathways, but is Notch-independent. We conclude that Ikaros is a crucial differentiation factor in early dendritic progenitors that is required for pDC identity. äIkaros cooperates with Notch activation and antagonizes TGF? signaling(epmc).pdf DeepDyve Pubget Overpricing