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10.1073/pnas.1802114115 http://scihub22266oqcxt.onion/10.1073/pnas.1802114115 C6042150!6042150!29891701     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (26): 6798-803 Nephropedia Template TP {{tp|p=29891701|t=2018. SUMO2 and SUMO3 redundantly prevent a noncanonical type I interferon response |pdf=|usr=}}{{29891701}} gab.com Text SUMO2 and SUMO3 redundantly prevent a noncanonical type I interferon response JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29891701 #FOAvip Type I interferons (IFNs) are cytokines that are essential for host defense against virus infection, but when they are inappropriately produced, they can cause severe autoimmune disease in humans. We have found that the sumoylation pathway of protein modification is essential for preventing an ectopic IFN response. Specifically, we have identified SUMO2 and SUMO3 as the two SUMO proteins that redundantly prevent IFN production. Remarkably, the potent IFN response caused by loss of SUMO2/3 is independent of all known inducers of the antiviral response, revealing a distinct mechanism of IFN production that has implications for our understanding of antiviral immunity. Twit Text FOAVip SUMO2 and SUMO3 redundantly prevent a noncanonical type I interferon response ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29891701 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29891701 #FOAvip English Wikipedia <ref>{{Cite pmid|29891701}}</ref> SUMO2 and SUMO3 redundantly prevent a noncanonical type I interferon response #MMPMID29891701 Crowl JT; Stetson DB Proc Natl Acad Sci U S A 2018[Jun]; 115 (26): 6798-803 PMID29891701show ga Type I interferons (IFNs) are cytokines that are essential for host defense against virus infection, but when they are inappropriately produced, they can cause severe autoimmune disease in humans. We have found that the sumoylation pathway of protein modification is essential for preventing an ectopic IFN response. Specifically, we have identified SUMO2 and SUMO3 as the two SUMO proteins that redundantly prevent IFN production. Remarkably, the potent IFN response caused by loss of SUMO2/3 is independent of all known inducers of the antiviral response, revealing a distinct mechanism of IFN production that has implications for our understanding of antiviral immunity. äSUMO2 and SUMO3 redundantly prevent a noncanonical type I interferon r(epmc).pdf DeepDyve Pubget Overpricing