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10.1038/s41598-018-28620-6

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suck abstract from ncbi


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pmid29992993
      Sci+Rep 2018 ; 8 (1 ): 10481
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  • Occupational radiation exposure and glaucoma and macular degeneration in the US radiologic technologists #MMPMID29992993
  • Little MP ; Kitahara CM ; Cahoon EK ; Bernier MO ; Velazquez-Kronen R ; Doody MM ; Borrego D ; Miller JS ; Alexander BH ; Simon SL ; Preston DL ; Meyer C ; Linet MS ; Hamada N
  • Sci Rep 2018[Jul]; 8 (1 ): 10481 PMID29992993 show ga
  • There are well-documented associations of glaucoma with high-dose radiation exposure, but only a single study suggesting risk of glaucoma, and less conclusively macular degeneration, associated with moderate-dose exposure. We assessed risk of glaucoma and macular degeneration associated with occupational eye-lens radiation dose, using participants from the US Radiologic Technologists Study, followed from the date of surveys in 1994-1998, 2003-2005 to the earliest of diagnosis of glaucoma or macular degeneration, cancer other than non-melanoma skin cancer, or date of last survey (2012-2014). We excluded those with baseline disease or previous radiotherapy history. Cox proportional hazards models with age as timescale were used. There were 1631 cases of newly self-reported doctor-diagnosed cases of glaucoma and 1331 of macular degeneration among 69,568 and 69,969 eligible subjects, respectively. Estimated mean cumulative eye-lens absorbed dose from occupational radiation exposures was 0.058?Gy. The excess relative risk/Gy for glaucoma was -0.57 (95% CI -1.46, 0.60, p?=?0.304) and for macular degeneration was 0.32 (95% CI -0.32, 1.27, p?=?0.381), suggesting that there is no appreciable risk for either endpoint associated with low-dose and low dose-rate radiation exposure. Since this is the first examination of glaucoma and macular degeneration associated with low-dose radiation exposure, this result needs to be replicated in other low-dose studies.
  • |*Occupational Exposure [MESH]
  • |*Radiation Exposure [MESH]
  • |Adult [MESH]
  • |Aged [MESH]
  • |Female [MESH]
  • |Glaucoma/epidemiology/*etiology [MESH]
  • |Humans [MESH]
  • |Macular Degeneration/epidemiology/*etiology [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Occupational Diseases/etiology [MESH]
  • |Risk Factors [MESH]
  • |Self Report [MESH]
  • |Surveys and Questionnaires [MESH]


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