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2018 ; 8
(1
): 10481
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Occupational radiation exposure and glaucoma and macular degeneration in the US
radiologic technologists
#MMPMID29992993
Little MP
; Kitahara CM
; Cahoon EK
; Bernier MO
; Velazquez-Kronen R
; Doody MM
; Borrego D
; Miller JS
; Alexander BH
; Simon SL
; Preston DL
; Meyer C
; Linet MS
; Hamada N
Sci Rep
2018[Jul]; 8
(1
): 10481
PMID29992993
show ga
There are well-documented associations of glaucoma with high-dose radiation
exposure, but only a single study suggesting risk of glaucoma, and less
conclusively macular degeneration, associated with moderate-dose exposure. We
assessed risk of glaucoma and macular degeneration associated with occupational
eye-lens radiation dose, using participants from the US Radiologic Technologists
Study, followed from the date of surveys in 1994-1998, 2003-2005 to the earliest
of diagnosis of glaucoma or macular degeneration, cancer other than non-melanoma
skin cancer, or date of last survey (2012-2014). We excluded those with baseline
disease or previous radiotherapy history. Cox proportional hazards models with
age as timescale were used. There were 1631 cases of newly self-reported
doctor-diagnosed cases of glaucoma and 1331 of macular degeneration among 69,568
and 69,969 eligible subjects, respectively. Estimated mean cumulative eye-lens
absorbed dose from occupational radiation exposures was 0.058?Gy. The excess
relative risk/Gy for glaucoma was -0.57 (95% CI -1.46, 0.60, p?=?0.304) and for
macular degeneration was 0.32 (95% CI -0.32, 1.27, p?=?0.381), suggesting that
there is no appreciable risk for either endpoint associated with low-dose and low
dose-rate radiation exposure. Since this is the first examination of glaucoma and
macular degeneration associated with low-dose radiation exposure, this result
needs to be replicated in other low-dose studies.