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2018 ; 13
(7
): e0199629
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Inferior long-term graft survival after end-to-side reconstruction for two renal
arteries in living donor renal transplantation
#MMPMID29995911
Yamanaga S
; Rosario A
; Fernandez D
; Kobayashi T
; Tavakol M
; Stock PG
; Kang SM
PLoS One
2018[]; 13
(7
): e0199629
PMID29995911
show ga
Living donor kidneys with two arteries can be revascularized using various
techniques depending on anatomy. We hypothesized that the revascularization
technique could impact long-term outcomes. We retrospectively analyzed 1714
living donor renal transplants at our institution between 1999 and 2015. Three
hundred and eleven kidneys had dual arteries, and these were categorized into 5
groups; end-to-side (n = 18), inferior epigastric artery (n = 21), direct
anastomosis (n = 65), side-to-side (n = 126) and ligated (n = 81). We then
compared the outcomes with that of a control group (single artery, n = 1403)
using Kaplan-Meier and Cox regression analyses. Cox regression was adjusted by
age, sex and race/ethnicity of donor and recipient, side of kidney, transplant
period and recipient surgeon. Compared to the control group, the end-to-side
group had increased all-cause graft loss (10 years: 77.2% vs 24.5%, adjusted
hazard ratio [aHR] 3.02, 95% confidence interval [CI] 1.30-7.03, p = 0.010) and
death-censored graft loss (10 years: 82.0% vs 55.9%, aHR 4.17, 95% CI 1.63-10.68,
p = 0.003), whereas the other groups did not. Our study shows that 10-year
overall survival and death-censored graft survival were significantly worse for
end-to-side arterial reconstruction than for other techniques. Alternative
techniques to the end-to-side method should be used for accessory arteries that
require revascularization.