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2018 ; 2018
(ä): 3753081
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The Imbalance between Foxp3(+)Tregs and Th1/Th17/Th22 Cells in Patients with
Newly Diagnosed Autoimmune Hepatitis
#MMPMID30050955
Liang M
; Liwen Z
; Yun Z
; Yanbo D
; Jianping C
J Immunol Res
2018[]; 2018
(ä): 3753081
PMID30050955
show ga
This study is aimed at examining the potential role of regulatory T- (Treg-)
Th1-Th17-Th22 cells in the pathogenic process of autoimmune hepatitis (AIH). The
numbers of Foxp3(+)Tregs and Th1, Th17, and Th22 cells were measured in 32 AIH
patients using flow cytometry. Moreover, a murine model of experimental
autoimmune hepatitis (EAH) was also established and used to investigate the
function of Treg-Th1-Th17-Th22 cells in disease progression. AIH patients
undergoing an active state had significantly decreased numbers of
CD3(+)CD4(+)CD25(+)Foxp3(+)Tregs and increased numbers of
CD3(+)CD4(+)CD25(-)Foxp3(+)T, CD3(+)CD4(+)IFN-?(+)Th1, CD3(+)CD4(+)IL-17(+)Th17,
and CD3(+)CD4(+)IL-2(+)Th22 cells as well as higher levels of Th1/Th17/Th22-type
cytokines compared to AIH patients in remission and HC. Additionally, the numbers
of CD3(+)CD4(+)CD25(+)Foxp3(+)Tregs were negatively correlated with the numbers
of Th1-Th17-Th22 cells. Also, the serum levels of IL-17A and IL-22 were
correlated positively with liver injury (ALT/AST), whereas the serum levels of
IL-10 were correlated negatively with hypergammaglobulinaemia (IgG, IgM) in AIH
patients. Interestingly, the percentages of spleen Tregs, expression of Foxp3
mRNA, and liver IL-10 levels decreased, whereas the percentages of spleen
Th1-Th17-Th22 cells, expression of T-bet/AHR/ROR?t mRNA, and liver IFN-?, IL-17,
and IL-22 levels increased in the murine model of EAH. Our findings demonstrated
that an imbalance between Tregs and Th1-Th17-Th22 cells might contribute to the
pathogenic process of AIH.
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