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10.1155/2018/1031367 http://scihub22266oqcxt.onion/10.1155/2018/1031367 C6040246!6040246 !30050950     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30050950 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Diabetes+Res 2018 ; 2018 (ä): 1031367 Nephropedia Template TP {{tp|p=30050950 |t=2018. Metformin Improves Epithelial-to-Mesenchymal Transition Induced by TGF-?1 in Renal Tubular Epithelial NRK-52E Cells via Inhibiting Egr-1 |pdf=|usr=}}{{30050950 }} gab.com Text Metformin Improves Epithelial-to-Mesenchymal Transition Induced by TGF- 1 in Renal Tubular Epithelial NRK-52E Cells via Inhibiting Egr-1 JO: J Diabetes Res http://www.kidney.de/pget.php?&tw=1&pmid=30050950 #FOAvip The early growth response- (Egr-) 1 has been found to play a key role in organ fibrosis. Metformin has been shown to be effective in attenuating renal tubular epithelial-to-mesenchymal transition (EMT), which is involved in renal fibrosis. However, it is unknown whether metformin improves EMT via inhibiting Egr-1. In this study, rat renal tubular epithelial (NRK-52 E) cells, treated by transforming growth factor- (TGF-) ?1 of 10?ng/ml with or without metformin of 1?mmol/l, were transfected by siEgr-1 or M61-Egr-1 plasmids to knock down or overexpress Egr-1, respectively. The gene and protein expressions of E-cadherin, ?-SMA, fibronectin (FN), and Egr-1 were determined by real-time quantitative PCR and Western blotting, respectively. We observed that TGF-?1 significantly reduced E-cadherin expression and upregulated the expressions of FN, ?-SMA, and Egr-1, which can be reversed by metformin. M61-Egr-1 transfection could exacerbate EMT, which can be reversed by metformin. Taken together, our data show that Egr-1 plays an important role in TGF-?1-induced EMT of renal tubular epithelial cells and metformin improves EMT while inhibiting Egr-1, which provides a potential novel target to combat renal fibrosis. Twit Text FOAVip Metformin Improves Epithelial-to-Mesenchymal Transition Induced by TGF- 1 in Renal Tubular Epithelial NRK-52E Cells via Inhibiting Egr-1 ????J Diabetes Res http://www.kidney.de/pget.php?&tw=1&pmid=30050950 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30050950 #FOAvip English Wikipedia <ref>{{Cite pmid|30050950 }}</ref> Metformin Improves Epithelial-to-Mesenchymal Transition Induced by TGF-?1 in Renal Tubular Epithelial NRK-52E Cells via Inhibiting Egr-1 #MMPMID30050950 Guan M ; Li W ; Xu L ; Zeng Y ; Wang D ; Zheng Z ; Lyv F ; Xue Y J Diabetes Res 2018[]; 2018 (ä): 1031367 PMID30050950 show ga The early growth response- (Egr-) 1 has been found to play a key role in organ fibrosis. Metformin has been shown to be effective in attenuating renal tubular epithelial-to-mesenchymal transition (EMT), which is involved in renal fibrosis. However, it is unknown whether metformin improves EMT via inhibiting Egr-1. In this study, rat renal tubular epithelial (NRK-52 E) cells, treated by transforming growth factor- (TGF-) ?1 of 10?ng/ml with or without metformin of 1?mmol/l, were transfected by siEgr-1 or M61-Egr-1 plasmids to knock down or overexpress Egr-1, respectively. The gene and protein expressions of E-cadherin, ?-SMA, fibronectin (FN), and Egr-1 were determined by real-time quantitative PCR and Western blotting, respectively. We observed that TGF-?1 significantly reduced E-cadherin expression and upregulated the expressions of FN, ?-SMA, and Egr-1, which can be reversed by metformin. M61-Egr-1 transfection could exacerbate EMT, which can be reversed by metformin. Taken together, our data show that Egr-1 plays an important role in TGF-?1-induced EMT of renal tubular epithelial cells and metformin improves EMT while inhibiting Egr-1, which provides a potential novel target to combat renal fibrosis. |*Epithelial-Mesenchymal Transition [MESH] |Animals [MESH] |Cell Line [MESH] |Early Growth Response Protein 1/genetics/*metabolism [MESH] |Epithelial Cells/*cytology [MESH] |Fibronectins/metabolism [MESH] |Gene Expression Regulation [MESH] |Gene Knockdown Techniques [MESH] |Humans [MESH] |Kidney Tubules/*cytology [MESH] |Metformin/*pharmacology [MESH] |Rats [MESH] |Recombinant Proteins/pharmacology [MESH] |Transfection [MESH] |Transforming Growth Factor beta1/*pharmacology [MESH]Metformin Improves Epithelial-to-Mesenchymal Transition Induced by TGF(epmc).pdf DeepDyve Pubget Overpricing