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10.2217/epi-2016-0096 http://scihub22266oqcxt.onion/10.2217/epi-2016-0096 C6040049!6040049!27885845     free     free     free       Epigenomics 2017 ; 9 (4): 505-25 Nephropedia Template TP {{tp|p=27885845|t=2017. DNA methylation in systemic lupus erythematosus |pdf=|usr=}}{{27885845}} gab.com Text DNA methylation in systemic lupus erythematosus JO: Epigenomics http://www.kidney.de/pget.php?&tw=1&pmid=27885845 #FOAvip Systemic lupus erythematosus (SLE) is a systemic autoimmune disease facilitated by aberrant immune responses directed against cells and tissues, resulting in inflammation and organ damage. In the majority of patients, genetic predisposition is accompanied by additional factors conferring disease expression. While the exact molecular mechanisms remain elusive, epigenetic alterations in immune cells have been demonstrated to play a key role in disease pathogenesis through the dysregulation of gene expression. Since epigenetic marks are dynamic, allowing cells and tissues to differentiate and adjust, they can be influenced by environmental factors and also be targeted in therapeutic interventions. Here, we summarize reports on DNA methylation patterns in SLE, underlying molecular defects and their effect on immune cell function. We discuss the potential of DNA methylation as biomarker or therapeutic target in SLE. Twit Text FOAVip DNA methylation in systemic lupus erythematosus ????Epigenomics http://www.kidney.de/pget.php?&tw=1&pmid=27885845 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27885845 #FOAvip English Wikipedia <ref>{{Cite pmid|27885845}}</ref> DNA methylation in systemic lupus erythematosus #MMPMID27885845 Hedrich CM; Mäbert K; Rauen T; Tsokos GC Epigenomics 2017[Apr]; 9 (4): 505-25 PMID27885845show ga Systemic lupus erythematosus (SLE) is a systemic autoimmune disease facilitated by aberrant immune responses directed against cells and tissues, resulting in inflammation and organ damage. In the majority of patients, genetic predisposition is accompanied by additional factors conferring disease expression. While the exact molecular mechanisms remain elusive, epigenetic alterations in immune cells have been demonstrated to play a key role in disease pathogenesis through the dysregulation of gene expression. Since epigenetic marks are dynamic, allowing cells and tissues to differentiate and adjust, they can be influenced by environmental factors and also be targeted in therapeutic interventions. Here, we summarize reports on DNA methylation patterns in SLE, underlying molecular defects and their effect on immune cell function. We discuss the potential of DNA methylation as biomarker or therapeutic target in SLE. äDNA methylation in systemic lupus erythematosus (epmc).pdf DeepDyve Pubget Overpricing