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2018 ; 71
(1
): 56-72.e4
Nephropedia Template TP
gab.com Text
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English Wikipedia
The Nucleosome Remodeling and Deacetylation Complex Modulates Chromatin Structure
at Sites of Active Transcription to Fine-Tune Gene Expression
#MMPMID30008319
Bornelöv S
; Reynolds N
; Xenophontos M
; Gharbi S
; Johnstone E
; Floyd R
; Ralser M
; Signolet J
; Loos R
; Dietmann S
; Bertone P
; Hendrich B
Mol Cell
2018[Jul]; 71
(1
): 56-72.e4
PMID30008319
show ga
Chromatin remodeling complexes play essential roles in metazoan development
through widespread control of gene expression, but the precise molecular
mechanisms by which they do this in vivo remain ill defined. Using an inducible
system with fine temporal resolution, we show that the nucleosome remodeling and
deacetylation (NuRD) complex controls chromatin architecture and the protein
binding repertoire at regulatory regions during cell state transitions. This is
primarily exerted through its nucleosome remodeling activity while deacetylation
at H3K27 follows changes in gene expression. Additionally, NuRD activity
influences association of RNA polymerase II at transcription start sites and
subsequent nascent transcript production, thereby guiding the establishment of
lineage-appropriate transcriptional programs. These findings provide a detailed
molecular picture of genome-wide modulation of lineage-specific transcription by
an essential chromatin remodeling complex as well as insight into the
orchestration of molecular events involved in transcriptional transitions
in vivo. VIDEO ABSTRACT.
|*Gene Expression Regulation
[MESH]
|*Transcription, Genetic
[MESH]
|Acetylation
[MESH]
|Animals
[MESH]
|Cell Line
[MESH]
|Histones/genetics/metabolism
[MESH]
|Mi-2 Nucleosome Remodeling and Deacetylase Complex/genetics/*metabolism
[MESH]