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10.1182/bloodadvances.2018018903 http://scihub22266oqcxt.onion/10.1182/bloodadvances.2018018903 C6039664!6039664 !29991496     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29991496 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Blood+Adv 2018 ; 2 (13 ): 1651-1663 Nephropedia Template TP {{tp|p=29991496 |t=2018. Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury |pdf=|usr=}}{{29991496 }} gab.com Text Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury JO: Blood Adv http://www.kidney.de/pget.php?&tw=1&pmid=29991496 #FOAvip Transfusion-related acute lung injury (TRALI) is a syndrome of respiratory distress upon blood transfusion and is the leading cause of transfusion-related fatalities. Whether the gut microbiota plays any role in the development of TRALI is currently unknown. We observed that untreated barrier-free (BF) mice suffered from severe antibody-mediated acute lung injury, whereas the more sterile housed specific pathogen-free (SPF) mice and gut flora-depleted BF mice were both protected from lung injury. The prevention of TRALI in the SPF mice and gut flora-depleted BF mice was associated with decreased plasma macrophage inflammatory protein-2 levels as well as decreased pulmonary neutrophil accumulation. DNA sequencing of amplicons of the 16S ribosomal RNA gene revealed a varying gastrointestinal bacterial composition between BF and SPF mice. BF fecal matter transferred into SPF mice significantly restored TRALI susceptibility in SPF mice. These data reveal a link between the gut flora composition and the development of antibody-mediated TRALI in mice. Assessment of gut microbial composition may help in TRALI risk assessment before transfusion. Twit Text FOAVip Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury ????Blood Adv http://www.kidney.de/pget.php?&tw=1&pmid=29991496 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29991496 #FOAvip English Wikipedia <ref>{{Cite pmid|29991496 }}</ref> Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury #MMPMID29991496 Kapur R ; Kim M ; Rebetz J ; Hallström B ; Björkman JT ; Takabe-French A ; Kim N ; Liu J ; Shanmugabhavananthan S ; Milosevic S ; McVey MJ ; Speck ER ; Semple JW Blood Adv 2018[Jul]; 2 (13 ): 1651-1663 PMID29991496 show ga Transfusion-related acute lung injury (TRALI) is a syndrome of respiratory distress upon blood transfusion and is the leading cause of transfusion-related fatalities. Whether the gut microbiota plays any role in the development of TRALI is currently unknown. We observed that untreated barrier-free (BF) mice suffered from severe antibody-mediated acute lung injury, whereas the more sterile housed specific pathogen-free (SPF) mice and gut flora-depleted BF mice were both protected from lung injury. The prevention of TRALI in the SPF mice and gut flora-depleted BF mice was associated with decreased plasma macrophage inflammatory protein-2 levels as well as decreased pulmonary neutrophil accumulation. DNA sequencing of amplicons of the 16S ribosomal RNA gene revealed a varying gastrointestinal bacterial composition between BF and SPF mice. BF fecal matter transferred into SPF mice significantly restored TRALI susceptibility in SPF mice. These data reveal a link between the gut flora composition and the development of antibody-mediated TRALI in mice. Assessment of gut microbial composition may help in TRALI risk assessment before transfusion. |*Gastrointestinal Microbiome [MESH] |Animals [MESH] |Chemokine CXCL2/*blood [MESH] |Lung/*metabolism/pathology [MESH] |Mice [MESH] |Neutrophils/*metabolism/pathology [MESH]Gastrointestinal microbiota contributes to the development of murine (epmc).pdf DeepDyve Pubget Overpricing