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10.1182/bloodadvances.2017015222 http://scihub22266oqcxt.onion/10.1182/bloodadvances.2017015222 C6039651!6039651 !29991495     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29991495 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Blood+Adv 2018 ; 2 (13 ): 1645-1650 Nephropedia Template TP {{tp|p=29991495 |t=2018. Ten-year outcome of patients with acute myeloid leukemia not treated with allogeneic transplantation in first complete remission |pdf=|usr=}}{{29991495 }} gab.com Text Ten-year outcome of patients with acute myeloid leukemia not treated with allogeneic transplantation in first complete remission JO: Blood Adv http://www.kidney.de/pget.php?&tw=1&pmid=29991495 #FOAvip The probability that adult patients with de novo acute myeloid leukemia (AML) receiving intensive chemotherapy in the absence of allogeneic hematopoietic stem cell transplantation (Allo-HCT) in first complete remission (CR1) will be disease-free at 10 years after diagnosis, a long-term surrogate of cure, is unknown. To address this question, we examined 2551 AML patients (1607 aged <60 years, and 944 aged ?60 years) enrolled in Cancer and Leukemia Group B treatment protocols and the cytogenetics companion protocol 8461 between 1983 and 2004. At 10 years, 267 (16.6%) of patients aged <60 years and 23 (2.4%) of those aged ?60 years were alive and disease-free. This disease-free AML group consisted predominantly of patients with core-binding factor AML with t(8;21)(q22;q22) or inv(16)(p13q22)/t(16;16)(p13;q22) and those with a normal karyotype. Occurrences of AML beyond 10 years were infrequent and associated with cytogenetic findings different from those at diagnosis. These data provide evidence that the frequency of long-term cure of AML is low among younger and especially older patients in the absence of Allo-HCT in CR1. In older patients not appropriate for Allo-HCT, these data provide further justification for early use of alternative treatments outside of intensive chemotherapy. Twit Text FOAVip Ten-year outcome of patients with acute myeloid leukemia not treated with allogeneic transplantation in first complete remission ????Blood Adv http://www.kidney.de/pget.php?&tw=1&pmid=29991495 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29991495 #FOAvip English Wikipedia <ref>{{Cite pmid|29991495 }}</ref> Ten-year outcome of patients with acute myeloid leukemia not treated with allogeneic transplantation in first complete remission #MMPMID29991495 Vasu S ; Kohlschmidt J ; Mrózek K ; Eisfeld AK ; Nicolet D ; Sterling LJ ; Becker H ; Metzeler KH ; Papaioannou D ; Powell BL ; Kolitz JE ; Moore JO ; Baer MR ; Roboz GJ ; Stone RM ; Byrd JC ; Carroll AJ ; Bloomfield CD Blood Adv 2018[Jul]; 2 (13 ): 1645-1650 PMID29991495 show ga The probability that adult patients with de novo acute myeloid leukemia (AML) receiving intensive chemotherapy in the absence of allogeneic hematopoietic stem cell transplantation (Allo-HCT) in first complete remission (CR1) will be disease-free at 10 years after diagnosis, a long-term surrogate of cure, is unknown. To address this question, we examined 2551 AML patients (1607 aged <60 years, and 944 aged ?60 years) enrolled in Cancer and Leukemia Group B treatment protocols and the cytogenetics companion protocol 8461 between 1983 and 2004. At 10 years, 267 (16.6%) of patients aged <60 years and 23 (2.4%) of those aged ?60 years were alive and disease-free. This disease-free AML group consisted predominantly of patients with core-binding factor AML with t(8;21)(q22;q22) or inv(16)(p13q22)/t(16;16)(p13;q22) and those with a normal karyotype. Occurrences of AML beyond 10 years were infrequent and associated with cytogenetic findings different from those at diagnosis. These data provide evidence that the frequency of long-term cure of AML is low among younger and especially older patients in the absence of Allo-HCT in CR1. In older patients not appropriate for Allo-HCT, these data provide further justification for early use of alternative treatments outside of intensive chemotherapy. |Abnormal Karyotype [MESH] |Adolescent [MESH] |Adult [MESH] |Age Factors [MESH] |Allografts [MESH] |Antineoplastic Combined Chemotherapy Protocols/*administration & dosage/adverse effects [MESH] |Disease-Free Survival [MESH] |Female [MESH] |Follow-Up Studies [MESH] |Hematopoietic Stem Cell Transplantation [MESH] |Humans [MESH] |Leukemia, Myeloid, Acute/*drug therapy/genetics/*mortality [MESH] |Male [MESH] |Middle Aged [MESH] |Retrospective Studies [MESH]Ten-year outcome of patients with acute myeloid leukemia not treated w(epmc).pdf DeepDyve Pubget Overpricing