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10.2147/OTT.S166149 http://scihub22266oqcxt.onion/10.2147/OTT.S166149 C6039056!6039056!30013371     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30013371&cmd=llinks): Failed to open stream: HTTP request failed! 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Integrated omics and gene expression analysis identifies the loss of metabolite?metabolite correlations in small cell lung cancer |pdf=|usr=}}{{30013371}} gab.com Text Integrated omics and gene expression analysis identifies the loss of metabolite metabolite correlations in small cell lung cancer JO: Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=30013371 #FOAvip Background and objective: Small cell lung cancer (SCLC) is the most aggressive type of lung carcinoma with high metastatic potential and chemoresistance upon relapse. Cancer cells remodel the existing metabolic pathways for their benefits and the perturbations in cellular metabolism are the hallmark of cancer. However, the extent of these changes remains largely unknown for SCLC. Materials and methods: We characterized the metabolic perturbations in SCLC cells (SCLCC) by metabolomics. Large-scale correlation analysis was performed between metabolites. Targeted proteomics and gene expression analysis were employed to investigate the changes of key enzymes and genes in the disturbed pathways. Results: We found dramatic decrease of metabolite?metabolite correlations in SCLCC compared with normal control cells and non-small cell lung cancer cells. Pathway analysis revealed that the loss of correlations was associated with the alternations of fatty acid oxidation, urea cycle, and purine salvage pathway in SCLCC. Targeted proteomics and gene expression analysis confirmed significant changes of the expression for the key enzymes and genes in the pathways in SCLCC including the upregulation of carbamoyl phosphate synthase 1 (urea cycle) and carnitine palmitoyltransferase 1A (fatty acid oxidation), and the downregulation of hypoxanthine?guanine phosphoribosyltransferase and adenine phosphoribosyltransferase in purine salvage pathway. Conclusion: We demonstrated the loss of metabolite?metabolite correlations in SCLCC associated with the upregulation of fatty acid oxidation and urea cycle and the downregulation of purine salvage pathways. Our findings provide insights into the metabolic reprogramming in SCLCC and highlight the potential therapeutic targets for the treatment of SCLC. Twit Text FOAVip Integrated omics and gene expression analysis identifies the loss of metabolite metabolite correlations in small cell lung cancer ????Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=30013371 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30013371 #FOAvip English Wikipedia <ref>{{Cite pmid|30013371}}</ref> Integrated omics and gene expression analysis identifies the loss of metabolite?metabolite correlations in small cell lung cancer #MMPMID30013371 Yu L; Li K; Xu Z; Cui G; Zhang X Onco Targets Ther 2018[]; 11 (ä): 3919-29 PMID30013371show ga Background and objective: Small cell lung cancer (SCLC) is the most aggressive type of lung carcinoma with high metastatic potential and chemoresistance upon relapse. Cancer cells remodel the existing metabolic pathways for their benefits and the perturbations in cellular metabolism are the hallmark of cancer. However, the extent of these changes remains largely unknown for SCLC. Materials and methods: We characterized the metabolic perturbations in SCLC cells (SCLCC) by metabolomics. Large-scale correlation analysis was performed between metabolites. Targeted proteomics and gene expression analysis were employed to investigate the changes of key enzymes and genes in the disturbed pathways. Results: We found dramatic decrease of metabolite?metabolite correlations in SCLCC compared with normal control cells and non-small cell lung cancer cells. Pathway analysis revealed that the loss of correlations was associated with the alternations of fatty acid oxidation, urea cycle, and purine salvage pathway in SCLCC. Targeted proteomics and gene expression analysis confirmed significant changes of the expression for the key enzymes and genes in the pathways in SCLCC including the upregulation of carbamoyl phosphate synthase 1 (urea cycle) and carnitine palmitoyltransferase 1A (fatty acid oxidation), and the downregulation of hypoxanthine?guanine phosphoribosyltransferase and adenine phosphoribosyltransferase in purine salvage pathway. Conclusion: We demonstrated the loss of metabolite?metabolite correlations in SCLCC associated with the upregulation of fatty acid oxidation and urea cycle and the downregulation of purine salvage pathways. Our findings provide insights into the metabolic reprogramming in SCLCC and highlight the potential therapeutic targets for the treatment of SCLC. äIntegrated omics and gene expression analysis identifies the loss of m(epmc).pdf DeepDyve Pubget Overpricing