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10.1371/journal.pone.0199206 http://scihub22266oqcxt.onion/10.1371/journal.pone.0199206 C6039005!6039005 !29990318     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29990318 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2018 ; 13 (7 ): e0199206 Nephropedia Template TP {{tp|p=29990318 |t=2018. An amyloidogenic hexapeptide derived from amylin attenuates inflammation and acute lung injury in murine sepsis |pdf=|usr=}}{{29990318 }} gab.com Text An amyloidogenic hexapeptide derived from amylin attenuates inflammation and acute lung injury in murine sepsis JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29990318 #FOAvip Although the accumulation of amyloidogenic proteins in neuroinflammatory conditions is generally considered pathologic, in a murine model of multiple sclerosis, amyloid-forming fibrils, comprised of hexapeptides, are anti-inflammatory. Whether these molecules modulate systemic inflammatory conditions remains unknown. We hypothesized that an amylin hexapeptide that forms fibrils can attenuate the systemic inflammatory response in a murine model of sepsis. To test this hypothesis, mice were pre-treated with either vehicle or amylin hexapeptide (20 ?g) at 12 hours and 6 hours prior to intraperitoneal (i.p.) lipopolysaccharide (LPS, 20 mg/kg) administration. Illness severity and survival were monitored every 6 hours for 3 days. Levels of pro- (IL-6, TNF-?, IFN-?) and anti-inflammatory (IL-10) cytokines were measured via ELISA at 1, 3, 6, 12, and 24 hours after LPS (i.p.). As a metric of lung injury, pulmonary artery endothelial cell (PAEC) barrier function was tested 24 hours after LPS administration by comparing lung wet-to-dry ratios, Evan's blue dye (EBD) extravasation, lung histology and caspase-3 activity. Compared to controls, pretreatment with amylin hexapeptide significantly reduced mortality (p<0.05 at 72 h), illness severity (p<0.05), and pro-inflammatory cytokine levels, while IL-10 levels were elevated (p<0.05). Amylin pretreatment attenuated LPS-induced lung injury, as demonstrated by decreased lung water and caspase-3 activity (p<0.05, versus PBS). Hence, in a murine model of systemic inflammation, pretreatment with amylin hexapeptide reduced mortality, disease severity, and preserved lung barrier function. Amylin hexapeptide may represent a novel therapeutic tool to mitigate sepsis severity and lung injury. Twit Text FOAVip An amyloidogenic hexapeptide derived from amylin attenuates inflammation and acute lung injury in murine sepsis ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29990318 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29990318 #FOAvip English Wikipedia <ref>{{Cite pmid|29990318 }}</ref> An amyloidogenic hexapeptide derived from amylin attenuates inflammation and acute lung injury in murine sepsis #MMPMID29990318 Mahapatra S ; Ying L ; Ho PP ; Kurnellas M ; Rothbard J ; Steinman L ; Cornfield DN PLoS One 2018[]; 13 (7 ): e0199206 PMID29990318 show ga Although the accumulation of amyloidogenic proteins in neuroinflammatory conditions is generally considered pathologic, in a murine model of multiple sclerosis, amyloid-forming fibrils, comprised of hexapeptides, are anti-inflammatory. Whether these molecules modulate systemic inflammatory conditions remains unknown. We hypothesized that an amylin hexapeptide that forms fibrils can attenuate the systemic inflammatory response in a murine model of sepsis. To test this hypothesis, mice were pre-treated with either vehicle or amylin hexapeptide (20 ?g) at 12 hours and 6 hours prior to intraperitoneal (i.p.) lipopolysaccharide (LPS, 20 mg/kg) administration. Illness severity and survival were monitored every 6 hours for 3 days. Levels of pro- (IL-6, TNF-?, IFN-?) and anti-inflammatory (IL-10) cytokines were measured via ELISA at 1, 3, 6, 12, and 24 hours after LPS (i.p.). As a metric of lung injury, pulmonary artery endothelial cell (PAEC) barrier function was tested 24 hours after LPS administration by comparing lung wet-to-dry ratios, Evan's blue dye (EBD) extravasation, lung histology and caspase-3 activity. Compared to controls, pretreatment with amylin hexapeptide significantly reduced mortality (p<0.05 at 72 h), illness severity (p<0.05), and pro-inflammatory cytokine levels, while IL-10 levels were elevated (p<0.05). Amylin pretreatment attenuated LPS-induced lung injury, as demonstrated by decreased lung water and caspase-3 activity (p<0.05, versus PBS). Hence, in a murine model of systemic inflammation, pretreatment with amylin hexapeptide reduced mortality, disease severity, and preserved lung barrier function. Amylin hexapeptide may represent a novel therapeutic tool to mitigate sepsis severity and lung injury. |Acute Lung Injury/chemically induced/*drug therapy/immunology/mortality [MESH] |Amyloidogenic Proteins/chemical synthesis/*pharmacology [MESH] |Animals [MESH] |Caspase 3/genetics/immunology [MESH] |Disease Models, Animal [MESH] |Endothelial Cells/drug effects/immunology/pathology [MESH] |Female [MESH] |Gene Expression Regulation [MESH] |Inflammation [MESH] |Interferon-gamma/genetics/immunology [MESH] |Interleukin-10/genetics/immunology [MESH] |Interleukin-6/genetics/immunology [MESH] |Islet Amyloid Polypeptide/*chemistry [MESH] |Lipopolysaccharides/administration & dosage [MESH] |Lung/*drug effects/immunology/pathology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Oligopeptides/chemical synthesis/*pharmacology [MESH] |Pulmonary Artery/drug effects/immunology/pathology [MESH] |Sepsis/chemically induced/*drug therapy/immunology/mortality [MESH] |Survival Analysis [MESH]An amyloidogenic hexapeptide derived from amylin attenuates inflammati(epmc).pdf DeepDyve Pubget Overpricing