Analysis of the Cancer Genome Atlas Data Reveals Novel Putative ncRNAs Targets in
Hepatocellular Carcinoma
#MMPMID30046591
Falcon T
; Freitas M
; Mello AC
; Coutinho L
; Alvares-da-Silva MR
; Matte U
Biomed Res Int
2018[]; 2018
(?): 2864120
PMID30046591
show ga
Hepatocellular carcinoma (HCC) is the prevalent type of primary liver malignancy.
Different noncoding RNAs (ncRNAs) that negatively regulate gene expression, such
as the microRNAs and the long ncRNAs (lncRNAs), have been associated with cell
invasiveness and cell dissemination, tumor recurrence, and metastasis in HCC. To
evaluate which regulatory ncRNAs might be good candidates to disrupt HCC
proliferation pathways, we performed both unsupervised and supervised analyses of
HCC expression data, comparing samples of solid tumor tissue (TP) and adjacent
tissue (NT) of a set of patients, focusing on ncRNAs and searching for common
mechanisms that may shed light in future therapeutic options. All analyses were
performed using the R software. Differential expression (total RNA and miRNA) and
enrichment analyses (Gene Ontology + Pathways) were performed using the package
TCGABiolinks. As a result, we improved the set of lncRNAs that could be the
target of future studies in HCC, highlighting the potential of FAM170B-AS1 and
TTN-AS1.
free
free
free
