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10.1186/s12967-018-1566-8

http://scihub22266oqcxt.onion/10.1186/s12967-018-1566-8
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suck abstract from ncbi


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pmid29986714
      J+Transl+Med 2018 ; 16 (1 ): 191
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  • The TGF?-signaling pathway and colorectal cancer: associations between dysregulated genes and miRNAs #MMPMID29986714
  • Pellatt AJ ; Mullany LE ; Herrick JS ; Sakoda LC ; Wolff RK ; Samowitz WS ; Slattery ML
  • J Transl Med 2018[Jul]; 16 (1 ): 191 PMID29986714 show ga
  • BACKGROUND: The TGF?-signaling pathway plays an important role in the pathogenesis of colorectal cancer (CRC). Loss of function of several genes within this pathway, such as bone morphogenetic proteins (BMPs) have been seen as key events in CRC progression. METHODS: In this study we comprehensively evaluate differential gene expression (RNASeq) of 81 genes in the TGF?-signaling pathway and evaluate how dysregulated genes are associated with miRNA expression (Agilent Human miRNA Microarray V19.0). We utilize paired carcinoma and normal tissue from 217 CRC cases. We evaluate the associations between differentially expressed genes and miRNAs and sex, age, disease stage, and survival months. RESULTS: Thirteen genes were significantly downregulated and 14 were significantly upregulated after considering fold change (FC) of?>?1.50 or?
  • |*Gene Expression Regulation, Neoplastic [MESH]
  • |Adult [MESH]
  • |Aged [MESH]
  • |Cell Line, Tumor [MESH]
  • |Colorectal Neoplasms/*genetics [MESH]
  • |Female [MESH]
  • |Gene Expression Profiling [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |MicroRNAs/*genetics/metabolism [MESH]
  • |Middle Aged [MESH]
  • |RNA, Messenger/genetics/metabolism [MESH]
  • |Signal Transduction/*genetics [MESH]
  • |Statistics, Nonparametric [MESH]


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