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10.1016/j.cmet.2018.05.003 http://scihub22266oqcxt.onion/10.1016/j.cmet.2018.05.003 C6038052!6038052!29861389     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Metab 2018 ; 28 (1): 159-174.e11 Nephropedia Template TP {{tp|p=29861389|t=2018. Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis |pdf=|usr=}}{{29861389}} gab.com Text Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=29861389 #FOAvip Activation of energy expenditure in thermogenic fat is a promising strategy to improve metabolic health, yet the dynamic processes that evoke this response are poorly understood. Here we show that synthesis of the mitochondrial phospholipid cardiolipin is indispensable for stimulating and sustaining thermogenic fat function. Cardiolipin biosynthesis is robustly induced in brown and beige adipose upon cold exposure. Mimicking this response through overexpression of cardiolipin synthase (Crls1) enhances energy consumption in mouse and human adipocytes. Crls1 deficiency in thermogenic adipocytes diminishes inducible mitochondrial uncoupling and elicits a nuclear transcriptional response through endoplasmic reticulum stress-mediated retrograde communication. Cardiolipin depletion in brown and beige fat abolishes adipose thermogenesis and glucose uptake, which renders animals insulin resistant. We further identify a rare human CRLS1 variant associated with insulin resistance and show that adipose CRLS1 levels positively correlate with insulin sensitivity. Thus, adipose cardiolipin has a powerful impact on organismal energy homeostasis through thermogenic fat bioenergetics. Twit Text FOAVip Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=29861389 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29861389 #FOAvip English Wikipedia <ref>{{Cite pmid|29861389}}</ref> Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis #MMPMID29861389 Sustarsic EG; Ma T; Lynes MD; Larsen M; Karavaeva I; Havelund JF; Nielsen CH; Jedrychowski MP; Moreno-Torres M; Lundh M; Plucinska K; Jespersen NZ; Grevengoed TJ; Kramar B; Peics J; Hansen JB; Shamsi F; Forss I; Neess D; Keipert S; Wang J; Stohlmann K; Brandslund I; Christensen C; Jørgensen ME; Linneberg A; Pedersen O; Kiebish MA; Qvortrup K; Han X; Pedersen BK; Jastroch M; Mandrup S; Kjær A; Gygi SP; Hansen T; Gillum MP; Grarup N; Emanuelli B; Nielsen S; Scheele C; Tseng YH; Færgeman NJ; Gerhart-Hines Z Cell Metab 2018[Jul]; 28 (1): 159-174.e11 PMID29861389show ga Activation of energy expenditure in thermogenic fat is a promising strategy to improve metabolic health, yet the dynamic processes that evoke this response are poorly understood. Here we show that synthesis of the mitochondrial phospholipid cardiolipin is indispensable for stimulating and sustaining thermogenic fat function. Cardiolipin biosynthesis is robustly induced in brown and beige adipose upon cold exposure. Mimicking this response through overexpression of cardiolipin synthase (Crls1) enhances energy consumption in mouse and human adipocytes. Crls1 deficiency in thermogenic adipocytes diminishes inducible mitochondrial uncoupling and elicits a nuclear transcriptional response through endoplasmic reticulum stress-mediated retrograde communication. Cardiolipin depletion in brown and beige fat abolishes adipose thermogenesis and glucose uptake, which renders animals insulin resistant. We further identify a rare human CRLS1 variant associated with insulin resistance and show that adipose CRLS1 levels positively correlate with insulin sensitivity. Thus, adipose cardiolipin has a powerful impact on organismal energy homeostasis through thermogenic fat bioenergetics. äCardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential(epmc).pdf DeepDyve Pubget Overpricing