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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Nephrol+Case+Stud
2018 ; 6
(ä): 16-20
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Successful rituximab treatment of TAFRO syndrome with pathological findings of
glomerular endothelial damage
#MMPMID30009125
Noda Y
; Saka Y
; Kato A
; Mimura T
; Naruse T
Clin Nephrol Case Stud
2018[]; 6
(ä): 16-20
PMID30009125
show ga
Thrombocytopenia, anasarca, fever, renal insufficiency, and organomegaly
constitute TAFRO syndrome, a variant of Castleman disease. We describe a patient
with TAFRO syndrome who underwent renal biopsy. A 79-year-old woman was referred
to us with fever and leg edema. She also had thrombocytopenia, pleural effusion,
ascites, and acute kidney injury, and was admitted to our hospital. Her response
to initial therapy with corticosteroid and cyclosporine was poor. Therefore, she
received 4 doses of rituximab per week, which resulted in clinical improvement,
including recovery of thrombocytopenia. A kidney biopsy thereafter showed
diffuse, global glomerular endothelial injury indicating thrombotic
microangiopathy (TMA). These findings suggested that TMA is associated with the
thrombocytopenia and renal insufficiency of TAFRO syndrome.