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2018 ; 6
(ä): 69
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A Review of FOXI3 Regulation of Development and Possible Roles in Cancer
Progression and Metastasis
#MMPMID30018953
Mukherjee A
; Hollern DP
; Williams OG
; Rayburn TS
; Byrd WA
; Yates C
; Jones JD
Front Cell Dev Biol
2018[]; 6
(ä): 69
PMID30018953
show ga
Development and cancer share a variety of functional traits such as EMT, cell
migration, angiogenesis, and tissue remodeling. In addition, many cellular
signaling pathways are noted to coordinate developmental processes and facilitate
aspects of tumor progression. The Forkhead box superfamily of transcription
factors consists of a highly conserved DNA binding domain, which binds to
specific DNA sequences and play significant roles during adult tissue
homoeostasis and embryogenesis including development, differentiation,
metabolism, proliferation, apoptosis, migration, and invasion. Interestingly,
various studies have implicated the role of key Fox family members such as FOXP,
FOXO, and FOXA during cancer initiation and metastases. FOXI3, a member of the
Forkhead family affects embryogenesis, development, and bone remodeling; however,
no studies have reported a role in cancer. In this review, we summarize the role
of FOXI3 in embryogenesis and bone development and discuss its potential
involvement in cancer progression with a focus on the bone metastasis. Moreover,
we hypothesize possible mechanisms underlying the role of FOXI3 in the
development of solid tumor bone metastasis.