Clinicopathological features and surgical outcomes of four rare subtypes of
primary liver carcinoma
#MMPMID30046230
Li Z
; Wu X
; Bi X
; Zhang Y
; Huang Z
; Lu H
; Zhao H
; Zhao J
; Zhou J
; Li M
; Ying J
; Cai J
Chin J Cancer Res
2018[Jun]; 30
(3
): 364-372
PMID30046230
show ga
OBJECTIVE: This study aimed to analyze clinicopathological and prognostic
features of four rare pathological subtypes of primary liver malignancies to make
better understanding of their clinical features. METHODS: The clinicopathological
data of 114 patients who were diagnosed with histologically proven four subtypes:
clear cell carcinoma (CCC), giant cell carcinoma (GCC), sarcomatoid carcinoma
(SC), and combined hepatocellular-cholangiocarcinoma (CHC) between October 1998
and August 2015 were reviewed. Their survival data were compared with those of
908 patients with histologically proven common hepatocellular carcinoma (HCC)
(early- and advanced-stage HCC) during the same period. RESULTS: The outcome of
the CCC group was better than that of the other three subgroups, and was similar
to that of the early-stage HCC group. Also, the smallest tumor size and the
highest incidence of pseudocapsule formation were observed in the CCC group. The
SC group had the worst outcome among these four subgroups; the prognosis was much
poorer than that of any other subgroups, even poorer than that of the
advanced-stage common HCC group. No statistical difference was observed between
the GCC, CHC and advanced-stage HCC groups on survival analysis. The incidences
of tumor vascular emboli, TNM staging and non-radical resection were three risk
factors of the prognosis. CONCLUSIONS: CCC is a low-degree malignancy and
relatively favorably prognostic subtype of HCC. However, GCC, SC, and CHC are
three rare high-degree malignancy subtypes of HCC with poor prognosis.
free
free
free
