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10.1021/acsnano.5b07756 http://scihub22266oqcxt.onion/10.1021/acsnano.5b07756 C6037489!6037489 !27070851     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27070851 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       ACS+Nano 2016 ; 10 (5 ): 5027-40 Nephropedia Template TP {{tp|p=27070851 |t=2016. Flow-Induced Crystallization of Collagen: A Potentially Critical Mechanism in Early Tissue Formation |pdf=|usr=}}{{27070851 }} gab.com Text Flow-Induced Crystallization of Collagen: A Potentially Critical Mechanism in Early Tissue Formation JO: ACS Nano http://www.kidney.de/pget.php?&tw=1&pmid=27070851 #FOAvip The type I collagen monomer is one of nature's most exquisite and prevalent structural tools. Its 300 nm triple-helical motifs assemble into tough extracellular fibers that transition seamlessly across tissue boundaries and exceed cell dimensions by up to 4 orders of magnitude. In spite of extensive investigation, no existing model satisfactorily explains how such continuous structures are generated and grown precisely where they are needed (aligned in the path of force) by discrete, microscale cells using materials with nanoscale dimensions. We present a simple fiber drawing experiment, which demonstrates that slightly concentrated type I collagen monomers can be "flow-crystallized" to form highly oriented, continuous, hierarchical fibers at cell-achievable strain rates (<1 s(-1)) and physiologically relevant concentrations (?50 ?M). We also show that application of tension following the drawing process maintains the structural integrity of the fibers. While mechanical tension has been shown to be a critical factor driving collagen fibril formation during tissue morphogenesis in developing animals, the precise role of force in the process of building tissue is not well understood. Our data directly couple mechanical tension, specifically the extensional strain rate, to collagen fibril assembly. We further derive a "growth equation" which predicts that application of extensional strains, either globally by developing muscles or locally by fibroblasts, can rapidly drive the fusion of already formed short fibrils to produce long-range, continuous fibers. The results provide a pathway to scalable connective tissue manufacturing and support a mechano-biological model of collagen fibril deposition and growth in vivo. Twit Text FOAVip Flow-Induced Crystallization of Collagen: A Potentially Critical Mechanism in Early Tissue Formation ????ACS Nano http://www.kidney.de/pget.php?&tw=1&pmid=27070851 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27070851 #FOAvip English Wikipedia <ref>{{Cite pmid|27070851 }}</ref> Flow-Induced Crystallization of Collagen: A Potentially Critical Mechanism in Early Tissue Formation #MMPMID27070851 Paten JA ; Siadat SM ; Susilo ME ; Ismail EN ; Stoner JL ; Rothstein JP ; Ruberti JW ACS Nano 2016[May]; 10 (5 ): 5027-40 PMID27070851 show ga The type I collagen monomer is one of nature's most exquisite and prevalent structural tools. Its 300 nm triple-helical motifs assemble into tough extracellular fibers that transition seamlessly across tissue boundaries and exceed cell dimensions by up to 4 orders of magnitude. In spite of extensive investigation, no existing model satisfactorily explains how such continuous structures are generated and grown precisely where they are needed (aligned in the path of force) by discrete, microscale cells using materials with nanoscale dimensions. We present a simple fiber drawing experiment, which demonstrates that slightly concentrated type I collagen monomers can be "flow-crystallized" to form highly oriented, continuous, hierarchical fibers at cell-achievable strain rates (<1 s(-1)) and physiologically relevant concentrations (?50 ?M). We also show that application of tension following the drawing process maintains the structural integrity of the fibers. While mechanical tension has been shown to be a critical factor driving collagen fibril formation during tissue morphogenesis in developing animals, the precise role of force in the process of building tissue is not well understood. Our data directly couple mechanical tension, specifically the extensional strain rate, to collagen fibril assembly. We further derive a "growth equation" which predicts that application of extensional strains, either globally by developing muscles or locally by fibroblasts, can rapidly drive the fusion of already formed short fibrils to produce long-range, continuous fibers. The results provide a pathway to scalable connective tissue manufacturing and support a mechano-biological model of collagen fibril deposition and growth in vivo. |*Crystallization [MESH] |Animals [MESH] |Collagen Type I/*chemistry [MESH] |Collagen/*chemistry [MESH] |Extracellular Matrix [MESH] |Stress, Mechanical [MESH]Flow-Induced Crystallization of Collagen: A Potentially Critical Mecha(epmc).pdf DeepDyve Pubget Overpricing