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10.4081/hr.2018.7419 http://scihub22266oqcxt.onion/10.4081/hr.2018.7419 C6036981!6036981!30046411     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hematol+Rep 2018 ; 10 (2): ä Nephropedia Template TP {{tp|p=30046411|t=2018. GBT440 reverses sickling of sickled red blood cells under hypoxic conditions in vitro |pdf=|usr=}}{{30046411}} gab.com Text GBT440 reverses sickling of sickled red blood cells under hypoxic conditions in vitro JO: Hematol Rep http://www.kidney.de/pget.php?&tw=1&pmid=30046411 #FOAvip Sickle cell disease is characterized by hemolytic anemia, vasoocclusion and early mortality. Polymerization of hemoglobin S followed by red blood cell sickling and subsequent vascular injury are key events in the pathogenesis of sickle cell disease. Sickled red blood cells are major contributors to the abnormal blood rheology, poor microvascular blood flow and endothelial injury in sickle cell disease. Therefore, an agent that can prevent and or reverse sickling of red blood cells, may provide therapeutic benefit for the treatment of sickle cell disease. We report here that GBT440, an anti-polymerization agent being developed for the chronic treatment of sickle cell disease, increases hemoglobin oxygen affinity and reverses in vitro sickling of previously sickled red blood cells under hypoxic conditions. Our results suggest that besides preventing sickling of red blood cells, GBT440 may mitigate vasoocclusion and microvascular dysfunction by reversing sickling of circulating sickled red blood cells in vivo. Twit Text FOAVip GBT440 reverses sickling of sickled red blood cells under hypoxic conditions in vitro ????Hematol Rep http://www.kidney.de/pget.php?&tw=1&pmid=30046411 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30046411 #FOAvip English Wikipedia <ref>{{Cite pmid|30046411}}</ref> GBT440 reverses sickling of sickled red blood cells under hypoxic conditions in vitro #MMPMID30046411 Dufu K; Oksenberg D Hematol Rep 2018[May]; 10 (2): ä PMID30046411show ga Sickle cell disease is characterized by hemolytic anemia, vasoocclusion and early mortality. Polymerization of hemoglobin S followed by red blood cell sickling and subsequent vascular injury are key events in the pathogenesis of sickle cell disease. Sickled red blood cells are major contributors to the abnormal blood rheology, poor microvascular blood flow and endothelial injury in sickle cell disease. Therefore, an agent that can prevent and or reverse sickling of red blood cells, may provide therapeutic benefit for the treatment of sickle cell disease. We report here that GBT440, an anti-polymerization agent being developed for the chronic treatment of sickle cell disease, increases hemoglobin oxygen affinity and reverses in vitro sickling of previously sickled red blood cells under hypoxic conditions. Our results suggest that besides preventing sickling of red blood cells, GBT440 may mitigate vasoocclusion and microvascular dysfunction by reversing sickling of circulating sickled red blood cells in vivo. äGBT440 reverses sickling of sickled red blood cells under hypoxic cond(epmc).pdf DeepDyve Pubget Overpricing