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10.3762/bjoc.14.144 http://scihub22266oqcxt.onion/10.3762/bjoc.14.144 C6036970!6036970!30013694     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30013694&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Beilstein+J+Org+Chem 2018 ; 14 (ä): 1693-703 Nephropedia Template TP {{tp|p=30013694|t=2018. Natural and redesigned wasp venom peptides with selective antitumoral activity |pdf=|usr=}}{{30013694}} gab.com Text Natural and redesigned wasp venom peptides with selective antitumoral activity JO: Beilstein J Org Chem http://www.kidney.de/pget.php?&tw=1&pmid=30013694 #FOAvip About 1 in 8 U.S. women (?12%) will develop invasive breast cancer over the course of their lifetime. Surgery, chemotherapy, radiotherapy, and hormone manipulation constitute the major treatment options for breast cancer. Here, we show that both a natural antimicrobial peptide (AMP) derived from wasp venom (decoralin, Dec-NH2), and its synthetic variants generated via peptide design, display potent activity against cancer cells. We tested the derivatives at increasing doses and observed anticancer activity at concentrations as low as 12.5 ?mol L?1 for the selective targeting of MCF-7 breast cancer cells. Flow cytometry assays further revealed that treatment with wild-type (WT) peptide Dec-NH2 led to necrosis of MCF-7 cells. Additional atomic force microscopy (AFM) measurements indicated that the roughness of cancer cell membranes increased significantly when treated with lead peptides compared to controls. Biophysical features such as helicity, hydrophobicity, and net positive charge were identified to play an important role in the anticancer activity of the peptides. Indeed, abrupt changes in peptide hydrophobicity and conformational propensity led to peptide inactivation, whereas increasing the net positive charge of peptides enhanced their activity. We present peptide templates with selective activity towards breast cancer cells that leave normal cells unaffected. These templates represent excellent scaffolds for the design of selective anticancer peptide therapeutics. Twit Text FOAVip Natural and redesigned wasp venom peptides with selective antitumoral activity ????Beilstein J Org Chem http://www.kidney.de/pget.php?&tw=1&pmid=30013694 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30013694 #FOAvip English Wikipedia <ref>{{Cite pmid|30013694}}</ref> Natural and redesigned wasp venom peptides with selective antitumoral activity #MMPMID30013694 Torres MDT; Andrade GP; Sato RH; Pedron CN; Manieri TM; Cerchiaro G; Ribeiro AO; de la Fuente-Nunez C; Oliveira VX Beilstein J Org Chem 2018[]; 14 (ä): 1693-703 PMID30013694show ga About 1 in 8 U.S. women (?12%) will develop invasive breast cancer over the course of their lifetime. Surgery, chemotherapy, radiotherapy, and hormone manipulation constitute the major treatment options for breast cancer. Here, we show that both a natural antimicrobial peptide (AMP) derived from wasp venom (decoralin, Dec-NH2), and its synthetic variants generated via peptide design, display potent activity against cancer cells. We tested the derivatives at increasing doses and observed anticancer activity at concentrations as low as 12.5 ?mol L?1 for the selective targeting of MCF-7 breast cancer cells. Flow cytometry assays further revealed that treatment with wild-type (WT) peptide Dec-NH2 led to necrosis of MCF-7 cells. Additional atomic force microscopy (AFM) measurements indicated that the roughness of cancer cell membranes increased significantly when treated with lead peptides compared to controls. Biophysical features such as helicity, hydrophobicity, and net positive charge were identified to play an important role in the anticancer activity of the peptides. Indeed, abrupt changes in peptide hydrophobicity and conformational propensity led to peptide inactivation, whereas increasing the net positive charge of peptides enhanced their activity. We present peptide templates with selective activity towards breast cancer cells that leave normal cells unaffected. These templates represent excellent scaffolds for the design of selective anticancer peptide therapeutics. äNatural and redesigned wasp venom peptides with selective antitumoral (epmc).pdf DeepDyve Pubget Overpricing