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10.14639/0392-100X-1693

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suck abstract from ncbi


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pmid29984799
      Acta+Otorhinolaryngol+Ital 2018 ; 38 (3 ): 225-228
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  • Bromelain s penetration into the blood and sinonasal mucosa in patients with chronic rhinosinusitis #MMPMID29984799
  • Passali D ; Passali GC ; Bellussi LM ; Sarafoleanu C ; Loglisci M ; Manea C ; Iosif C ; Passali FM
  • Acta Otorhinolaryngol Ital 2018[Jun]; 38 (3 ): 225-228 PMID29984799 show ga
  • The aim of this research is to investigate penetration of Bromelain into sinonasal mucosa in patients with chronic rhinosinusitis (CRS) versus a control group. Bromelain is derived from pineapple (Ananas comosus) and has various pharmacological effects. 40 patients (20 patients and 20 controls) were enrolled in the study. Bromelain 500 mg tablet twice daily was administered for 30 days. We scored bromelain presence in turbinate and ethmoid mucosas and in the serum of both the groups. Bromelain has an excellent distribution from blood to rhinosinusal mucosa. Its diffusion ability may allow the use of bromelain as an anti-inflammatory agent in paranasal sinus pathologies.
  • |Adult [MESH]
  • |Aged [MESH]
  • |Bromelains/administration & dosage/*blood/*pharmacokinetics [MESH]
  • |Chronic Disease [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Nasal Mucosa/*metabolism [MESH]
  • |Paranasal Sinuses/*metabolism [MESH]
  • |Rhinitis/complications/drug therapy/*metabolism [MESH]
  • |Sinusitis/complications/drug therapy/*metabolism [MESH]
  • |Tissue Distribution [MESH]


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