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Long non-coding RNA CRYBG3 regulates glycolysis of lung cancer cells by
interacting with lactate dehydrogenase A
#MMPMID30026857
Chen H
; Pei H
; Hu W
; Ma J
; Zhang J
; Mao W
; Nie J
; Xu C
; Li B
; Hei TK
; Wang C
; Zhou G
J Cancer
2018[]; 9
(14
): 2580-2588
PMID30026857
show ga
Cancer cells usually utilize glucose as a carbon source for aerobic glycolysis, a
phenomenon known as the Warburg effect. And a high rate of glycolysis has been
observed in lung cancer cells. The growing evidence indicates that long
non-coding RNAs (lncRNAs) are important players in lung cancer initiation and
progression. However, the correlation between lncRNAs and glycolysis remains
unclear. In this study, we recognized a lncRNA, LNC CRYBG3, which can interact
with lactate dehydrogenase A (LDHA), a vital enzyme of glycolysis, is highly
upregulated in both clinical lung cancer tissues and in vitro cultured lung
cancer cell lines. A positive correlation between the expression level of LNC
CRYBG3 and LDHA expression levels is observed. In another hand, LNC CRYBG3 is a
regulator of glycolysis and its overexpression promoted the uptake of glucose and
the production of lactate whereas the knockdown of LNC CRYBG3 led to opposite
results and suppressed cell proliferation. These results indicated that LNC
CRYBG3 might be a novel target for lung cancer treatment.
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