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2018 ; 9
(13
): 2317-2326
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MicroRNA-1296 Facilitates Proliferation, Migration And Invasion Of Colorectal
Cancer Cells By Targeting SFPQ
#MMPMID30026827
Tao Y
; Ma C
; Fan Q
; Wang Y
; Han T
; Sun C
J Cancer
2018[]; 9
(13
): 2317-2326
PMID30026827
show ga
MicroRNAs (miRNAs) are involved in cancer genesis and progression via acting as
tumor suppressors or oncogenes. Previous studies report that miR-1296 shows
upregulation in both colorectal cancer (CRC) tissues and plasma samples. However,
the accurate clinical significance of miR-1296 and its role in CRC have not been
well investigated. The aim of the present study was to disclose the aberrant
expression, clinical significance, and the relevant biological function of
miR-1296 in CRC. We found a marked upregulation of miR-1296 expression in CRC
tissues compared to tumor-adjacent tissues. MiR-1296 overexpression was detected
in five CRC cell lines (HCT116, Caco2, HT29, SW620 and SW480). High miR-1296
level was remarkably correlated with tumor size (>5cm), lymph node metastasis and
TNM stage (III+IV). Notably. High miR-1296 expression was identified as a
predictive factor for poor prognosis of CRC patients by survival analysis.
MiR-1296 knockdown inhibited proliferation, migration, invasion capacities of
HCT116 and SW480 cells in vitro. Moreover, miR-1296 silencing restrained the
growth of CRC cells in vivo. Splicing factor proline and glutamine rich (SFPQ), a
novel RNA binding protein, was identified as a direct target gene of miR-1296 in
CRC. Downregulation of SFPQ expression was inversely associated with miR-1296
expression in CRC tissues. The Cancer Genome Atlas (TCGA) data revealed the
prognostic value of dysregulated SFPQ in CRC patients. Interestingly, our
findings established that the oncogenic role of miR-1296 was at least partially
mediated by SFPQ in CRC cells. Collectively, these data indicate that miR-1296
accelerates CRC progression possibly by targeting SFPQ and may serve as a
potential predictive factor and therapeutic target for CRC.
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