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2018 ; 9
(13
): 2397-2407
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Prognostic Values of CCNE1 Amplification and Overexpression in Cancer Patients: A
Systematic Review and Meta-analysis
#MMPMID30026836
Zhao H
; Wang J
; Zhang Y
; Yuan M
; Yang S
; Li L
; Yang H
J Cancer
2018[]; 9
(13
): 2397-2407
PMID30026836
show ga
A number of studies revealed that CCNE1 copy number amplification and
overexpression (on mRNA or protein expression level) were associated with
prognosis of diverse cancers, however, the results were inconsistent among
studies. So we conducted this systematic review and meta-analysis to investigate
the prognostic values of CCNE1 amplification and overexpression in cancer
patients. PubMed, Cochrane library, Embase, CNKI and WanFang database (last
update by February 15, 2018) were searched for literatures. A total of 20 studies
were included and 5 survival assessment parameters were measured in this study,
which included overall survival (OS), progression free survival (PFS), recurrence
free survival (RFS), cancer specific survival (CSS) and distant metastasis free
survival (DMFS). Pooled analyses showed that CCNE1 amplification might predict
poor OS (HR=1.59, 95% CI: 1.05-2.40, p=0.027) rather than PFS (HR=1.49, 95% CI:
0.83-2.67, p=0.177) and RFS (HR=0.982, 95% CI: 0.2376-4.059, p=0.9801) in various
cancers; CCNE1 overexpression significantly correlated with poor OS (HR=1.52, 95%
CI: 1.05-2.20, p=0.027), PFS (HR=1.20, 95% CI: 1.07-1.34, p=0.001) and DMFS
(HR=1.62, 95% CI: 1.09-2.40, p=0.017) rather than RFS (HR=1.68, 95% CI:
0.81-3.50, p=0.164) and CSS (HR=1.54, 95% CI: 0.74-3.18, p=0.246). On the whole,
these results indicated CCNE1 amplification and overexpression were associated
with poor survival of patients with cancer, suggesting that CCNE1 might be an
effective prognostic signature for cancer patients.