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10.3892/ol.2018.8905 http://scihub22266oqcxt.onion/10.3892/ol.2018.8905 C6036559!6036559!30013659     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncol+Lett 2018 ; 16 (2): 2638-44 Nephropedia Template TP {{tp|p=30013659|t=2018. miRNA-29a inhibits colon cancer growth by regulation of the PTEN/Akt/GSK3? and Wnt/?-catenin signaling pathways |pdf=|usr=}}{{30013659}} gab.com Text miRNA-29a inhibits colon cancer growth by regulation of the PTEN/Akt/GSK3 and Wnt/ -catenin signaling pathways JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=30013659 #FOAvip In the present study, the effects of microRNA-29a (miRNA-29a) on colon cancer cell viability and the molecular mechanisms underlying the effects were investigated. The expression of miRNA-29a in colon cancer serum samples was notably downregulated, compared with in the normal group. First, miRNA-29a mimic was used to increase the expression of miRNA-29a in HCT-116 cells. Furthermore, upregulation of miRNA-29a suppressed cell viability, increased lactate dehydrogenase levels and apoptosis, and promoted caspase-3/9 activities and B-cell lymphoma 2-associated X protein and phosphatase and tensin homolog (PTEN) protein expression in colon cancer cells. Furthermore, upregulation of miRNA-29a decreased phosphoinositide 3-kinase, phosphorylated (p)-protein kinase B (Akt) and p-glycogen synthase kinase 3? (GSK3?) protein expression and suppressed the Wnt/?-catenin signaling pathway in colon cancer cells. The results of the present study verified that the protective effects of miRNA-29a suppress the PTEN/Akt/GSK3? and Wnt/?-catenin signaling pathways in colon cancer. Twit Text FOAVip miRNA-29a inhibits colon cancer growth by regulation of the PTEN/Akt/GSK3 and Wnt/ -catenin signaling pathways ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=30013659 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30013659 #FOAvip English Wikipedia <ref>{{Cite pmid|30013659}}</ref> miRNA-29a inhibits colon cancer growth by regulation of the PTEN/Akt/GSK3? and Wnt/?-catenin signaling pathways #MMPMID30013659 Han X; Zheng J; Wang Y; Gao Z Oncol Lett 2018[Aug]; 16 (2): 2638-44 PMID30013659show ga In the present study, the effects of microRNA-29a (miRNA-29a) on colon cancer cell viability and the molecular mechanisms underlying the effects were investigated. The expression of miRNA-29a in colon cancer serum samples was notably downregulated, compared with in the normal group. First, miRNA-29a mimic was used to increase the expression of miRNA-29a in HCT-116 cells. Furthermore, upregulation of miRNA-29a suppressed cell viability, increased lactate dehydrogenase levels and apoptosis, and promoted caspase-3/9 activities and B-cell lymphoma 2-associated X protein and phosphatase and tensin homolog (PTEN) protein expression in colon cancer cells. Furthermore, upregulation of miRNA-29a decreased phosphoinositide 3-kinase, phosphorylated (p)-protein kinase B (Akt) and p-glycogen synthase kinase 3? (GSK3?) protein expression and suppressed the Wnt/?-catenin signaling pathway in colon cancer cells. The results of the present study verified that the protective effects of miRNA-29a suppress the PTEN/Akt/GSK3? and Wnt/?-catenin signaling pathways in colon cancer. ämiRNA-29a inhibits colon cancer growth by regulation of the PTEN/Akt/G(epmc).pdf DeepDyve Pubget Overpricing