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10.3892/ol.2018.8967

http://scihub22266oqcxt.onion/10.3892/ol.2018.8967
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C6036472!6036472!30008925
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suck abstract from ncbi


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pmid30008925      Oncol+Lett 2018 ; 16 (2): 2243-50
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  • MicroRNA-1294 inhibited oral squamous cell carcinoma growth by targeting c-Myc #MMPMID30008925
  • Wang Z; Yan J; Zou T; Gao H
  • Oncol Lett 2018[Aug]; 16 (2): 2243-50 PMID30008925show ga
  • Oral squamous cell carcinoma (OSCC) is the predominant histological type of oral cancer. The 5-year survival rate of OSCC is only ~50%. c-Myc is a known oncogene and target gene in various cancer types, including OSCC. The presnet study revealed that c-Myc is one of the target genes of miR-1294. Results indicated lower levels of miR-1294 in OSCC tissues samples collected from 24 patients with OSCC. Notably, overexpression of miR-1294 inhibited proliferation and migration in OSCC cell lines and inhibition of miR-1294 promoted cell growth and migration in OSCC cell lines. Moreover, miR-1294 can target the 3?UTR of c-Myc, as we identified a negative correlation between c-Myc mRNA expression and miR-1294 expression in 24 OSCC tissues. In conclusion, the data demonstrate the tumor suppressive role of miR-1294 in OSCC.
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