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2018 ; 15
(10
): 978-985
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Endothelial-cell inflammation and damage by reactive oxygen species are prevented
by propofol via ABCA1-mediated cholesterol efflux
#MMPMID30013438
Hsu CP
; Lin CH
; Kuo CY
Int J Med Sci
2018[]; 15
(10
): 978-985
PMID30013438
show ga
Background: Cholesterol efflux efficiency, reactive oxygen species, and
inflammation are closely related to cardiovascular diseases. Our aim was to
investigate the effect of propofol on cholesterol-loaded rat aortic endothelial
cells after high-density lipoprotein treatment in vitro. Methods and Results: The
results showed that propofol promoted cholesterol efflux and ameliorated
inflammation and reactive oxygen species overproduction according to the analysis
of p65 nuclear translocation and a 2',7'-dichlorofluorescin diacetate assay,
respectively. Conclusions: These results provide a possible explanation for the
anti-inflammatory, antioxidant, and cholesterol efflux-promoting effects of
propofol on rat aortic endothelial cells after incubation with high-density
lipoprotein.