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2018 ; 15
(9
): 892-899
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
A high frequency of CD8(+)CD28(-) T-suppressor cells contributes to maintaining
stable graft function and reducing immunosuppressant dosage after liver
transplantation
#MMPMID30008601
Geng L
; Liu J
; Huang J
; Lin B
; Yu S
; Shen T
; Wang Z
; Yang Z
; Zhou L
; Zheng S
Int J Med Sci
2018[]; 15
(9
): 892-899
PMID30008601
show ga
CD8(+)CD28(-)T cells (CD8Ts) exert immunosuppressive effects in various
autoimmune diseases. The current study was designed to investigate the role of
defects in CD8Ts in liver transplantation (LT). The proportion of CD8Ts in
peripheral blood was determined by flow cytometry. The mean proportion of CD8Ts
was 23.39% in recipients with stable graft function and 16.64% in those with
graft dysfunction following LT compared with 19.86% in the healthy cohort. After
receiving enhanced immunosuppressive therapy, patients in the rejection group who
achieved recovery of graft function showed an increase in the proportion of CD8Ts
(from 17.39% to 25.55%), but those in the group with refractory graft dysfunction
showed no significant change (12.49% to 10.30%). Furthermore, in the first year
after LT, recipients longer removed in time from the LT date exhibited a higher
proportion of CD8Ts. Patients benefited most from tacrolimus concentrations of
5-10 ng/ml in the first year after LT and 0-5 ng/ml thereafter. Moreover, the
change in the proportion of CD8Ts (?CD8Ts) was significantly higher in recipients
with stable graft function than in those with graft dysfunction. These results
suggest that a high frequency of CD8Ts prevents rejection and contributes to
reduce immunosuppressant dosage and even induces tolerance.