Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41375-018-0035-y http://scihub22266oqcxt.onion/10.1038/s41375-018-0035-y C6035145!6035145!29472722     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Leukemia 2018 ; 32 (7): 1609-20 Nephropedia Template TP {{tp|p=29472722|t=2018. Chromothripsis in acute myeloid leukemia: biological features and impact on survival |pdf=|usr=}}{{29472722}} gab.com Text Chromothripsis in acute myeloid leukemia: biological features and impact on survival JO: Leukemia http://www.kidney.de/pget.php?&tw=1&pmid=29472722 #FOAvip Chromothripsis is a one-step genome-shattering catastrophe resulting from disruption of one or few chromosomes in multiple fragments and consequent random rejoining and repair. This study defines incidence of chromothripsis in 395 newly diagnosed adult acute myeloid leukemia (AML) patients from three institutions, its impact on survival and its genomic background. SNP 6.0 or CytoscanHD Array (Affymetrix®) were performed on all samples. We detected chromothripsis with a custom algorithm in 26/395 patients. Patients harboring chromothripsis had higher age (p?=?0.002), ELN high risk (HR) (p?<?0.001), lower white blood cell (WBC) count (p?=?0.040), TP53 loss, and/or mutations (p?<?0.001) while FLT3 (p?=?0.025), and NPM1 (p?=?0.032) mutations were mutually exclusive with chromothripsis. Chromothripsis-positive patients showed a worse overall survival (OS) (p?<?0.001) compared with HR patients (p?=?0.011) and a poor prognosis in a COX-HR optimal regression model. Chromothripsis presented the hallmarks of chromosome instability [i.e., TP53 alteration, 5q deletion, higher mean of copy number alteration (CNA), complex karyotype, alterations in DNA repair, and cell cycle] and focal deletions on chromosomes 4, 7, 12, 16, and 17. CBA. FISH showed that chromothripsis is associated with marker, derivative, and ring chromosomes. In conclusion, chromothripsis frequently occurs in AML (6.6%) and influences patient prognosis and disease biology. Twit Text FOAVip Chromothripsis in acute myeloid leukemia: biological features and impact on survival ????Leukemia http://www.kidney.de/pget.php?&tw=1&pmid=29472722 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29472722 #FOAvip English Wikipedia <ref>{{Cite pmid|29472722}}</ref> Chromothripsis in acute myeloid leukemia: biological features and impact on survival #MMPMID29472722 Fontana MC; Marconi G; Feenstra JDM; Fonzi E; Papayannidis C; Ghelli Luserna di Rorá A; Padella A; Solli V; Franchini E; Ottaviani E; Ferrari A; Baldazzi C; Testoni N; Iacobucci I; Soverini S; Haferlach T; Guadagnuolo V; Semerad L; Doubek M; Steurer M; Racil Z; Paolini S; Manfrini M; Cavo M; Simonetti G; Kralovics R; Martinelli G Leukemia 2018[]; 32 (7): 1609-20 PMID29472722show ga Chromothripsis is a one-step genome-shattering catastrophe resulting from disruption of one or few chromosomes in multiple fragments and consequent random rejoining and repair. This study defines incidence of chromothripsis in 395 newly diagnosed adult acute myeloid leukemia (AML) patients from three institutions, its impact on survival and its genomic background. SNP 6.0 or CytoscanHD Array (Affymetrix®) were performed on all samples. We detected chromothripsis with a custom algorithm in 26/395 patients. Patients harboring chromothripsis had higher age (p?=?0.002), ELN high risk (HR) (p? äChromothripsis in acute myeloid leukemia: biological features and impa(epmc).pdf DeepDyve Pubget Overpricing