Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29576028
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Int+Neuropsychol+Soc
2018 ; 24
(6
): 531-539
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Anomalous Brain Development Is Evident in Preschoolers With
Attention-Deficit/Hyperactivity Disorder
#MMPMID29576028
Jacobson LA
; Crocetti D
; Dirlikov B
; Slifer K
; Denckla MB
; Mostofsky SH
; Mahone EM
J Int Neuropsychol Soc
2018[Jul]; 24
(6
): 531-539
PMID29576028
show ga
OBJECTIVES: Attention-deficit/hyperactivity disorder (ADHD) is a common
neurological disorder with symptom onset early in childhood. Growing evidence
suggests anomalous brain development across multiple brain regions is evident in
school-aged children; however, few studies have examined whether such differences
are notable in the preschool years when symptom onset typically occurs. METHODS:
High resolution anatomical (MPRAGE) images and cognitive and behavioral measures
were analyzed in a total of 90 medication-naïve preschoolers, ages 4-5 years (52
with ADHD, 38 controls; 64.4% boys). RESULTS: Results revealed reductions in
bilateral frontal, parietal, and temporal lobe gray matter volumes in children
with ADHD relative to typically developing children, with largest effect sizes
noted for right frontal and left temporal lobe volumes. Examining frontal lobe
sub-regions, the largest between group effect sizes were evident for left
orbitofrontal cortex, left primary motor cortex (M1), and left supplementary
motor complex (SMC). ADHD-related reductions in specific sub-regions (left
prefrontal, left premotor, left frontal eye field, left M1, and right SMC) were
significantly correlated with symptom severity, such that higher ratings of
hyperactive/impulsive symptoms were associated with reduced cortical volumes.
CONCLUSIONS: These findings represent the first comprehensive examination of
cortical volume in preschool children with ADHD, providing evidence that
anomalous brain structure in ADHD is evident very early in development.
Furthermore, findings set the stage for developing our understanding of the way
in which developmental trajectories of anomalous brain development are associated
with the unfolding of symptoms in childhood ADHD. (JINS, 2018, 24, 531-539).
|Attention Deficit Disorder with Hyperactivity/*pathology/*physiopathology
[MESH]