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10.2450/2017.0354-16

http://scihub22266oqcxt.onion/10.2450/2017.0354-16
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C6034771!6034771 !29313798
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suck abstract from ncbi


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pmid29313798
      Blood+Transfus 2018 ; 16 (4 ): 371-381
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  • Current challenges in the diagnosis and management of patients with inherited von Willebrand s disease in Italy: an Expert Meeting Report on the diagnosis and surgical and secondary long-term prophylaxis #MMPMID29313798
  • Schinco P ; Castaman G ; Coppola A ; Cultrera D ; Ettorre C ; Giuffrida AC ; Marchesini E ; Marino R ; Milan M ; Molinari C ; Siboni SM ; Zanon E ; Federici AB
  • Blood Transfus 2018[Jul]; 16 (4 ): 371-381 PMID29313798 show ga
  • Recent advances in the care of von Willebrand's disease (vWD) have allowed the majority of patients to be managed adequately. Even in the more severe forms, it is now possible to control recurrent bleeding through secondary long-term prophylaxis with von Willebrand factor-containing concentrates. Moreover, in the setting of surgical prophylaxis, the combination of interdisciplinary management and close patient monitoring yields a positive outcome in nearly all cases, although safety concerns remain. In clinical practice, the effectiveness of therapy is hindered by the difficulties in making a rapid, yet accurate diagnosis, in identifying the subgroup of bleeders who may benefit most from a specific strategy, and in selecting the optimal product and regimen.Since specific guidelines for heavy bleeders requiring short- and long-term prophylaxis are still lacking, sharing the experience of experts dealing with vWD patients on a daily basis is crucial to fill gaps in information relating to patient management. To address this important issue, 13 Italian haematologists met in Milan on April, 2, 2016 and in Florence on July, 9, 2016. A 30-question survey constituted the input to discuss (i) optimisation of the diagnostic workflow for vWD, (ii) the characteristics of patients who may benefit from secondary long-term prophylaxis (in particular with the purified von Willebrand factor concentrate with a low content of factor VIII), (iii) the key elements to consider when selecting a concentrate and (iv) the pre-operative and post-operative management of vWD patients. A summary of the main points covered is provided in this report.
  • |Congresses as Topic [MESH]
  • |Humans [MESH]
  • |Italy [MESH]
  • |Practice Guidelines as Topic [MESH]


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