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10.1016/j.gene.2014.07.056 http://scihub22266oqcxt.onion/10.1016/j.gene.2014.07.056 C6034679!6034679!25062971     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Gene 2014 ; 549 (1): 134-40 Nephropedia Template TP {{tp|p=25062971|t=2014. Role for IL-10 in the transcriptional regulation of Roquin-1 |pdf=|usr=}}{{25062971}} gab.com Text Role for IL-10 in the transcriptional regulation of Roquin-1 JO: Gene http://www.kidney.de/pget.php?&tw=1&pmid=25062971 #FOAvip Roquin-1, a RING finger E3 ubiquitin ligase, functions as a modulator of inflammation; however, nothing is known about how Rc3h1 expression is regulated. Here, we describe an opposing relationship between Roquin-1 and the IL-17 proinflammatory cytokine by demonstrating that enforced expression of Rc3h1 restricts Il17a expression, and that exposure of T cells to IL-10, a cytokine with immunosuppressive activity, increases Rc3h1 expression. Luciferase reporter assays conducted using eight transcription factor plasmids (STAT1, STAT3, STAT5, GATA2, c-Rel, IKZF1, IKZF2, and IKZF3) demonstrated that STAT1, STAT3, GATA2, and c-Rel increased Rc3h1 promoter activity, whereas IKZF2 decreased activity. Gene expression of those five transcription factors increased in T cells exposed to IL-10. Transcription factor-specific siRNAs suppressed the IL-10 effect on Rc3h1 transcription. These findings identify a role for IL-10 in regulating Rc3h1 transcription, and they have implications for understanding how Roquin-1 controls the immune response. Twit Text FOAVip Role for IL-10 in the transcriptional regulation of Roquin-1 ????Gene http://www.kidney.de/pget.php?&tw=1&pmid=25062971 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25062971 #FOAvip English Wikipedia <ref>{{Cite pmid|25062971}}</ref> Role for IL-10 in the transcriptional regulation of Roquin-1 #MMPMID25062971 Schaefer JS; Montufar-Solis D; Klein JR Gene 2014[Oct]; 549 (1): 134-40 PMID25062971show ga Roquin-1, a RING finger E3 ubiquitin ligase, functions as a modulator of inflammation; however, nothing is known about how Rc3h1 expression is regulated. Here, we describe an opposing relationship between Roquin-1 and the IL-17 proinflammatory cytokine by demonstrating that enforced expression of Rc3h1 restricts Il17a expression, and that exposure of T cells to IL-10, a cytokine with immunosuppressive activity, increases Rc3h1 expression. Luciferase reporter assays conducted using eight transcription factor plasmids (STAT1, STAT3, STAT5, GATA2, c-Rel, IKZF1, IKZF2, and IKZF3) demonstrated that STAT1, STAT3, GATA2, and c-Rel increased Rc3h1 promoter activity, whereas IKZF2 decreased activity. Gene expression of those five transcription factors increased in T cells exposed to IL-10. Transcription factor-specific siRNAs suppressed the IL-10 effect on Rc3h1 transcription. These findings identify a role for IL-10 in regulating Rc3h1 transcription, and they have implications for understanding how Roquin-1 controls the immune response. äRole for IL-10 in the transcriptional regulation of Roquin-1 (epmc).pdf DeepDyve Pubget Overpricing