Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29991937
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Gastroenterol+Hepatol+(N+Y)
2018 ; 14
(5
): 293-304
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Primary Sclerosing Cholangitis, Part 1: Epidemiology, Etiopathogenesis, Clinical
Features, and Treatment
#MMPMID29991937
Tabibian JH
; Ali AH
; Lindor KD
Gastroenterol Hepatol (N Y)
2018[May]; 14
(5
): 293-304
PMID29991937
show ga
Primary sclerosing cholangitis (PSC) is a chronic, idiopathic cholangiopathy that
can progress to cirrhosis, end-stage liver disease, hepatobiliary cancer, and/or
colorectal cancer. The course of PSC is often complicated by portal hypertension,
symptoms of cholestasis, and recurrent bacterial cholangitis, among other
conditions, with a consequent decrease in survival (median, approximately 20
years) and quality of life. The etiopathogenesis of PSC remains poorly
understood, and, as such, pharmacotherapy has yet to be definitively established.
Despite its rarity, PSC is the fifth leading indication for liver transplantation
(LT) in the United States. Although the only intervention known to extend
survival of patients with PSC, LT is costly and invasive, and recurrent PSC
affects approximately 30% of LT recipients. Over the past several years, owing in
part to progress in the understanding of PSC, novel pharmacotherapeutics have
been developed, some of which are currently in the PSC clinical trial pipeline.
Here, in the first of a 2-part series, we provide a review and update of the
epidemiology, etiopathogenesis, clinical features, and treatment of PSC. The
second part of the series will focus on cancer risk, prevention, and surveillance
of PSC.