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10.15252/emmm.201708307 http://scihub22266oqcxt.onion/10.15252/emmm.201708307 C6034131!6034131 !29844217     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29844217 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+Mol+Med 2018 ; 10 (7 ): ä Nephropedia Template TP {{tp|p=29844217 |t=2018. The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting |pdf=|usr=}}{{29844217 }} gab.com Text The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting JO: EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=29844217 #FOAvip Activation of AMPK has been associated with pro-atrophic signaling in muscle. However, AMPK also has anti-inflammatory effects, suggesting that in cachexia, a syndrome of inflammatory-driven muscle wasting, AMPK activation could be beneficial. Here we show that the AMPK agonist AICAR suppresses IFN?/TNF?-induced atrophy, while the mitochondrial inhibitor metformin does not. IFN?/TNF? impair mitochondrial oxidative respiration in myotubes and promote a metabolic shift to aerobic glycolysis, similarly to metformin. In contrast, AICAR partially restored metabolic function. The effects of AICAR were prevented by the AMPK inhibitor Compound C and were reproduced with A-769662, a specific AMPK activator. AICAR and A-769662 co-treatment was found to be synergistic, suggesting that the anti-cachectic effects of these drugs are mediated through AMPK activation. AICAR spared muscle mass in mouse models of cancer and LPS induced atrophy. Together, our findings suggest a dual function for AMPK during inflammation-driven atrophy, wherein it can play a protective role when activated exogenously early in disease progression, but may contribute to anabolic suppression and atrophy when activated later through mitochondrial dysfunction and subsequent metabolic stress. Twit Text FOAVip The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting ????EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=29844217 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29844217 #FOAvip English Wikipedia <ref>{{Cite pmid|29844217 }}</ref> The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting #MMPMID29844217 Hall DT ; Griss T ; Ma JF ; Sanchez BJ ; Sadek J ; Tremblay AMK ; Mubaid S ; Omer A ; Ford RJ ; Bedard N ; Pause A ; Wing SS ; Di Marco S ; Steinberg GR ; Jones RG ; Gallouzi IE EMBO Mol Med 2018[Jul]; 10 (7 ): ä PMID29844217 show ga Activation of AMPK has been associated with pro-atrophic signaling in muscle. However, AMPK also has anti-inflammatory effects, suggesting that in cachexia, a syndrome of inflammatory-driven muscle wasting, AMPK activation could be beneficial. Here we show that the AMPK agonist AICAR suppresses IFN?/TNF?-induced atrophy, while the mitochondrial inhibitor metformin does not. IFN?/TNF? impair mitochondrial oxidative respiration in myotubes and promote a metabolic shift to aerobic glycolysis, similarly to metformin. In contrast, AICAR partially restored metabolic function. The effects of AICAR were prevented by the AMPK inhibitor Compound C and were reproduced with A-769662, a specific AMPK activator. AICAR and A-769662 co-treatment was found to be synergistic, suggesting that the anti-cachectic effects of these drugs are mediated through AMPK activation. AICAR spared muscle mass in mouse models of cancer and LPS induced atrophy. Together, our findings suggest a dual function for AMPK during inflammation-driven atrophy, wherein it can play a protective role when activated exogenously early in disease progression, but may contribute to anabolic suppression and atrophy when activated later through mitochondrial dysfunction and subsequent metabolic stress. |AMP-Activated Protein Kinase Kinases [MESH] |Aminoimidazole Carboxamide/*analogs & derivatives/therapeutic use [MESH] |Animals [MESH] |Cachexia/etiology/*prevention & control [MESH] |Cell Line [MESH] |Enzyme Activation [MESH] |Inflammation/complications [MESH] |Interferon-gamma/antagonists & inhibitors [MESH] |Male [MESH] |Metformin/*therapeutic use [MESH] |Mice, Inbred BALB C [MESH] |Mitochondria/drug effects [MESH] |Muscle, Skeletal/drug effects/enzymology [MESH] |Neoplasms, Experimental/pathology [MESH] |Nitric Oxide Synthase Type II/metabolism [MESH] |Protein Kinases/drug effects/*metabolism [MESH] |Ribonucleotides/*therapeutic use [MESH] |Shock, Septic/chemically induced/complications [MESH]The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR)(epmc).pdf DeepDyve Pubget Overpricing