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10.18632/oncotarget.25586 http://scihub22266oqcxt.onion/10.18632/oncotarget.25586 C6033344!6033344!29983885     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2018 ; 9 (47): 28625-37 Nephropedia Template TP {{tp|p=29983885|t=2018. RIOK1 kinase activity is required for cell survival irrespective of MTAP status |pdf=|usr=}}{{29983885}} gab.com Text RIOK1 kinase activity is required for cell survival irrespective of MTAP status JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29983885 #FOAvip Genotype specific vulnerabilities of cancer cells constitute a promising strategy for the development of new therapeutics. Deletions of non-essential genes in tumors can generate unique vulnerabilities which could be exploited therapeutically. The MTAP gene is recurrently deleted in human cancers because of its chromosomal proximity to the tumor suppressor gene CDKN2A. Recent studies have uncovered an increased dependency of MTAP-deleted cancer cells on the function of a PRMT5 containing complex, including WDR77, PRMT5 and the kinase RIOK1. As RIOK1 kinase activity constitutes a potential therapeutic target, we wanted to test if MTAP deletion confers increased sensitivity to RIOK1 inhibition. Using CRISPR/Cas9-mediated genome engineering we generated analog sensitive alleles of RIOK1 in isogenic cell lines differing only by MTAP status. While we were able to independently confirm an increased dependency of MTAP-deleted cells on PRMT5, we did not detect a differential requirement for RIOK1 kinase activity between MTAP-proficient and deficient cells. Our results reveal that the kinase activity of RIOK1 is required for the survival of cancer cell lines irrespective of their MTAP status and cast doubt on the therapeutic exploitability of RIOK1 in the context of MTAP-deleted cancers. Twit Text FOAVip RIOK1 kinase activity is required for cell survival irrespective of MTAP status ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29983885 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29983885 #FOAvip English Wikipedia <ref>{{Cite pmid|29983885}}</ref> RIOK1 kinase activity is required for cell survival irrespective of MTAP status #MMPMID29983885 Hörmann A; Hopfgartner B; Köcher T; Corcokovic M; Krammer T; Reiser C; Bader G; Shi J; Ehrenhöfer K; Wöhrle S; Schweifer N; Vakoc CR; Kraut N; Pearson M; Petronczki M; Neumüller RA Oncotarget 2018[Jun]; 9 (47): 28625-37 PMID29983885show ga Genotype specific vulnerabilities of cancer cells constitute a promising strategy for the development of new therapeutics. Deletions of non-essential genes in tumors can generate unique vulnerabilities which could be exploited therapeutically. The MTAP gene is recurrently deleted in human cancers because of its chromosomal proximity to the tumor suppressor gene CDKN2A. Recent studies have uncovered an increased dependency of MTAP-deleted cancer cells on the function of a PRMT5 containing complex, including WDR77, PRMT5 and the kinase RIOK1. As RIOK1 kinase activity constitutes a potential therapeutic target, we wanted to test if MTAP deletion confers increased sensitivity to RIOK1 inhibition. Using CRISPR/Cas9-mediated genome engineering we generated analog sensitive alleles of RIOK1 in isogenic cell lines differing only by MTAP status. While we were able to independently confirm an increased dependency of MTAP-deleted cells on PRMT5, we did not detect a differential requirement for RIOK1 kinase activity between MTAP-proficient and deficient cells. Our results reveal that the kinase activity of RIOK1 is required for the survival of cancer cell lines irrespective of their MTAP status and cast doubt on the therapeutic exploitability of RIOK1 in the context of MTAP-deleted cancers. äRIOK1 kinase activity is required for cell survival irrespective of MT(epmc).pdf DeepDyve Pubget Overpricing