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Circulating CD14(+)CD163(+)CD206(+) M2 Monocytes Are Increased in Patients with
Early Stage of Idiopathic Membranous Nephropathy
#MMPMID30034290
Hou J
; Zhang M
; Ding Y
; Wang X
; Li T
; Gao P
; Jiang Y
Mediators Inflamm
2018[]; 2018
(?): 5270657
PMID30034290
show ga
AIM: To analyze changes in peripheral blood monocytes and their clinical
significance in patients with early stage of idiopathic membranous nephropathy
(IMN). METHODS: A total of 27 patients with early stage of IMN and 16 age- and
sex-matched healthy controls (HCs) were recruited for the study. The monocyte
subset counts in circulation were measured by flow cytometry, and serum
interleukin- (IL-) 10 and IL-12 concentrations were tested by enzyme-linked
immunosorbent assay. The potential association between clinical signs and
monocyte subset counts was analyzed statistically. RESULTS: Compared with the
HCs, the patients with early stage of IMN had higher counts of CD14(+)CD163(+),
CD14(+)CD163(+)CD206(+), and CD14(+)CD163(+)CD206(+)CD115(+) M2-like monocytes.
The CD14(+)CD163(+)CD206(+) M2-like cell counts and intracellular IL-10
concentrations in the monocytes were positively correlated with progression in
proteinuria. The levels of serum IL-10 were significantly higher in early IMN
patients than in the HCs. Furthermore, CD14(+)CD163(+)CD206(+) M2-like cell
counts in the patients with incipient IMN were also positively related with 24?h
urinary albumin levels and the values of serum M-type phospholipase A2 receptor
(PLA2R). CONCLUSION: CD14(+)CD163(+)CD206(+) M2-like monocytes may contribute to
the pathologic process in early-stage IMN and could serve as potential markers
for evaluating the disease severity.
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