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2018 ; 19
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): ä Nephropedia Template TP
gab.com Text
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English Wikipedia
Pathophysiological Mechanisms of Chronic Venous Disease and Implications for
Venoactive Drug Therapy
#MMPMID29874834
Mansilha A
; Sousa J
Int J Mol Sci
2018[Jun]; 19
(6
): ä PMID29874834
show ga
Chronic venous disease (CVD) is a common pathology, with significant physical and
psychological impacts for patients and high economic costs for national
healthcare systems. Throughout the last decades, several risk factors for this
condition have been identified, but only recently, have the roles of inflammation
and endothelial dysfunction been properly assessed. Although still incompletely
understood, current knowledge of the pathophysiological mechanisms of CVD reveals
several potential targets and strategies for therapeutic intervention, some of
which are addressable by currently available venoactive drugs. The roles of these
drugs in the clinical improvement of venous tone and contractility, reduction of
edema and inflammation, as well as in improved microcirculation and venous ulcer
healing have been studied extensively, with favorable results reported in the
literature. Here, we aim to review these pathophysiological mechanisms and their
implications regarding currently available venoactive drug therapies.