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10.3390/ijms19061712 http://scihub22266oqcxt.onion/10.3390/ijms19061712 C6032334!6032334 !29890734     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29890734 &cmd=llinks): Failed to open stream: HTTP request failed! 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The Impact of the Nitric Oxide (NO)/Soluble Guanylyl Cyclase (sGC) Signaling Cascade on Kidney Health and Disease: A Preclinical Perspective |pdf=|usr=}}{{29890734 }} gab.com Text The Impact of the Nitric Oxide (NO)/Soluble Guanylyl Cyclase (sGC) Signaling Cascade on Kidney Health and Disease: A Preclinical Perspective JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29890734 #FOAvip Chronic Kidney Disease (CKD) is a highly prevalent disease with a substantial medical need for new and more efficacious treatments. The Nitric Oxide (NO), soluble guanylyl cyclase (sGC), cyclic guanosine monophosphate (cGMP) signaling cascade regulates various kidney functions. cGMP directly influences renal blood flow, renin secretion, glomerular function, and tubular exchange processes. Downregulation of NO/sGC/cGMP signaling results in severe kidney pathologies such as CKD. Therefore, treatment strategies aiming to maintain or increase cGMP might have beneficial effects for the treatment of progressive kidney diseases. Within this article, we review the NO/sGC/cGMP signaling cascade and its major pharmacological intervention sites. We specifically focus on the currently known effects of cGMP on kidney function parameters. Finally, we summarize the preclinical evidence for kidney protective effects of NO-donors, PDE inhibitors, sGC stimulators, and sGC activators. Twit Text FOAVip The Impact of the Nitric Oxide (NO)/Soluble Guanylyl Cyclase (sGC) Signaling Cascade on Kidney Health and Disease: A Preclinical Perspective ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29890734 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29890734 #FOAvip English Wikipedia <ref>{{Cite pmid|29890734 }}</ref> The Impact of the Nitric Oxide (NO)/Soluble Guanylyl Cyclase (sGC) Signaling Cascade on Kidney Health and Disease: A Preclinical Perspective #MMPMID29890734 Krishnan SM ; Kraehling JR ; Eitner F ; Bénardeau A ; Sandner P Int J Mol Sci 2018[Jun]; 19 (6 ): ä PMID29890734 show ga Chronic Kidney Disease (CKD) is a highly prevalent disease with a substantial medical need for new and more efficacious treatments. The Nitric Oxide (NO), soluble guanylyl cyclase (sGC), cyclic guanosine monophosphate (cGMP) signaling cascade regulates various kidney functions. cGMP directly influences renal blood flow, renin secretion, glomerular function, and tubular exchange processes. Downregulation of NO/sGC/cGMP signaling results in severe kidney pathologies such as CKD. Therefore, treatment strategies aiming to maintain or increase cGMP might have beneficial effects for the treatment of progressive kidney diseases. Within this article, we review the NO/sGC/cGMP signaling cascade and its major pharmacological intervention sites. We specifically focus on the currently known effects of cGMP on kidney function parameters. Finally, we summarize the preclinical evidence for kidney protective effects of NO-donors, PDE inhibitors, sGC stimulators, and sGC activators. |*Signal Transduction [MESH] |Animals [MESH] |Cyclic GMP/metabolism [MESH] |Humans [MESH] |Kidney Diseases/*pathology/therapy [MESH] |Kidney/*pathology [MESH] |Nitric Oxide/*metabolism [MESH]The Impact of the Nitric Oxide (NO)/Soluble Guanylyl Cyclase (sGC) Sig(epmc).pdf DeepDyve Pubget Overpricing