Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3390/ijms19061729 http://scihub22266oqcxt.onion/10.3390/ijms19061729 C6032240!6032240 !29891777     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29891777 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2018 ; 19 (6 ): ä Nephropedia Template TP {{tp|p=29891777 |t=2018. Caveolin-1 Scaffolding Domain Peptides Alleviate Liver Fibrosis by Inhibiting TGF-?1/Smad Signaling in Mice |pdf=|usr=}}{{29891777 }} gab.com Text Caveolin-1 Scaffolding Domain Peptides Alleviate Liver Fibrosis by Inhibiting TGF- 1/Smad Signaling in Mice JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29891777 #FOAvip Liver fibrosis is the common pathological process characterized by activation of hepatic stellate cells (HSCs) and overproduction of extracellular matrix (ECM). Caveolin-1 (Cav1), the principal component of caveolae, is regarded as an important inhibitor of multiple signaling molecules including transforming growth factor ?1(TGF-?1) signaling. To evaluate the role of Cav1 in liver fibrosis, Cav1 deficient (Cav1(?/?)) and wild type (WT) mice were subjected to liver fibrosis induced by carbon tetrachloride (CCl?). Results indicated no significant difference between Cav1(?/?) and WT mice in inflammation or collagen content before CCl? treatment. After CCl? administration, Cav1(?/?) mice showed enhanced TGF-?1 signaling, as reflected by a significantly greater amount of phosphorylation of Smad2 and collagen deposition in livers over WT animals. Qualitative and quantitative analysis indicated that inflammatory injury to the liver was markedly aggravated, accompanied by increased degeneration and necrosis of hepatocytes, higher alanine aminotransferase (ALT)/aspartate aminotransferase (AST), TGF-? and IL-1? levels in Cav1(?/?) animals. The mRNA and protein levels of ?-smooth muscle actin (?-SMA), Collagen ?1(I), and Collagen ?1(III) were further enhanced in Cav1(?/?) animals. We also observed a significant decrease in collagen content in Cav1(?/?) and WT animals administrated with Cav1 scaffolding domain peptides (CSD). In vitro study indicated that phosphorylation of Smad2 was inhibited after CSD treatment, accompanied by decreased protein levels of ?-SMA, Collagen ?1(I), and Collagen ?1(III) in HSCs. We conclude that Cav1 is an important inhibitor of TGF-?1/Smad signaling in HSCs activation and collagen production, which might make it a promising target for therapy of liver fibrosis. Twit Text FOAVip Caveolin-1 Scaffolding Domain Peptides Alleviate Liver Fibrosis by Inhibiting TGF- 1/Smad Signaling in Mice ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29891777 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29891777 #FOAvip English Wikipedia <ref>{{Cite pmid|29891777 }}</ref> Caveolin-1 Scaffolding Domain Peptides Alleviate Liver Fibrosis by Inhibiting TGF-?1/Smad Signaling in Mice #MMPMID29891777 Lu J ; Zhang J ; Wang Y ; Sun Q Int J Mol Sci 2018[Jun]; 19 (6 ): ä PMID29891777 show ga Liver fibrosis is the common pathological process characterized by activation of hepatic stellate cells (HSCs) and overproduction of extracellular matrix (ECM). Caveolin-1 (Cav1), the principal component of caveolae, is regarded as an important inhibitor of multiple signaling molecules including transforming growth factor ?1(TGF-?1) signaling. To evaluate the role of Cav1 in liver fibrosis, Cav1 deficient (Cav1(?/?)) and wild type (WT) mice were subjected to liver fibrosis induced by carbon tetrachloride (CCl?). Results indicated no significant difference between Cav1(?/?) and WT mice in inflammation or collagen content before CCl? treatment. After CCl? administration, Cav1(?/?) mice showed enhanced TGF-?1 signaling, as reflected by a significantly greater amount of phosphorylation of Smad2 and collagen deposition in livers over WT animals. Qualitative and quantitative analysis indicated that inflammatory injury to the liver was markedly aggravated, accompanied by increased degeneration and necrosis of hepatocytes, higher alanine aminotransferase (ALT)/aspartate aminotransferase (AST), TGF-? and IL-1? levels in Cav1(?/?) animals. The mRNA and protein levels of ?-smooth muscle actin (?-SMA), Collagen ?1(I), and Collagen ?1(III) were further enhanced in Cav1(?/?) animals. We also observed a significant decrease in collagen content in Cav1(?/?) and WT animals administrated with Cav1 scaffolding domain peptides (CSD). In vitro study indicated that phosphorylation of Smad2 was inhibited after CSD treatment, accompanied by decreased protein levels of ?-SMA, Collagen ?1(I), and Collagen ?1(III) in HSCs. We conclude that Cav1 is an important inhibitor of TGF-?1/Smad signaling in HSCs activation and collagen production, which might make it a promising target for therapy of liver fibrosis. |*Signal Transduction [MESH] |Animals [MESH] |Carbon Tetrachloride [MESH] |Caveolin 1/*chemistry/deficiency/*metabolism [MESH] |Cells, Cultured [MESH] |Collagen Type I/metabolism [MESH] |Down-Regulation/drug effects/genetics [MESH] |Hepatic Stellate Cells/drug effects/metabolism/pathology [MESH] |Inflammation/pathology [MESH] |Liver Cirrhosis/*drug therapy/*metabolism/pathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Peptides/pharmacology/*therapeutic use [MESH] |Phosphorylation/drug effects [MESH] |Protein Domains [MESH] |Smad Proteins/*metabolism [MESH]Caveolin-1 Scaffolding Domain Peptides Alleviate Liver Fibrosis by Inh(epmc).pdf DeepDyve Pubget Overpricing