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10.3390/ijms19061568 http://scihub22266oqcxt.onion/10.3390/ijms19061568 C6032192!6032192!29795022     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29795022.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2018 ; 19 (6): ä Nephropedia Template TP {{tp|p=29795022|t=2018. Signaling Crosstalk of TGF-?/ALK5 and PAR2/PAR1: A Complex Regulatory Network Controlling Fibrosis and Cancer |pdf=|usr=}}{{29795022}} gab.com Text Signaling Crosstalk of TGF- /ALK5 and PAR2/PAR1: A Complex Regulatory Network Controlling Fibrosis and Cancer JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29795022 #FOAvip Both signaling by transforming growth factor-? (TGF-?) and agonists of the G Protein-coupled receptors proteinase-activated receptor-1 (PAR1) and -2 (PAR2) have been linked to tissue fibrosis and cancer. Intriguingly, TGF-? and PAR signaling either converge on the regulation of certain matrix genes overexpressed in these pathologies or display mutual regulation of their signaling components, which is mediated in part through sphingosine kinases and sphingosine-1-phosphate and indicative of an intimate signaling crosstalk between the two pathways. In the first part of this review, we summarize the various regulatory interactions that have been discovered so far according to the organ/tissue in which they were described. In the second part, we highlight the types of signaling crosstalk between TGF-? on the one hand and PAR2/PAR1 on the other hand. Both ligand?receptor systems interact at various levels and by several mechanisms including mutual regulation of ligand?ligand, ligand?receptor, and receptor?receptor at the transcriptional, post-transcriptional, and receptor transactivation levels. These mutual interactions between PAR2/PAR1 and TGF-? signaling components eventually result in feed-forward loops/vicious cycles of matrix deposition and malignant traits that exacerbate fibrosis and oncogenesis, respectively. Given the crucial role of PAR2 and PAR1 in controlling TGF-? receptor activation, signaling, TGF-? synthesis and bioactivation, combining PAR inhibitors with TGF-? blocking agents may turn out to be more efficient than targeting TGF-? alone in alleviating unwanted TGF-?-dependent responses but retaining the beneficial ones. Twit Text FOAVip Signaling Crosstalk of TGF- /ALK5 and PAR2/PAR1: A Complex Regulatory Network Controlling Fibrosis and Cancer ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29795022 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29795022 #FOAvip English Wikipedia <ref>{{Cite pmid|29795022}}</ref> Signaling Crosstalk of TGF-?/ALK5 and PAR2/PAR1: A Complex Regulatory Network Controlling Fibrosis and Cancer #MMPMID29795022 Ungefroren H; Gieseler F; Kaufmann R; Settmacher U; Lehnert H; Rauch BH Int J Mol Sci 2018[Jun]; 19 (6): ä PMID29795022show ga Both signaling by transforming growth factor-? (TGF-?) and agonists of the G Protein-coupled receptors proteinase-activated receptor-1 (PAR1) and -2 (PAR2) have been linked to tissue fibrosis and cancer. Intriguingly, TGF-? and PAR signaling either converge on the regulation of certain matrix genes overexpressed in these pathologies or display mutual regulation of their signaling components, which is mediated in part through sphingosine kinases and sphingosine-1-phosphate and indicative of an intimate signaling crosstalk between the two pathways. In the first part of this review, we summarize the various regulatory interactions that have been discovered so far according to the organ/tissue in which they were described. In the second part, we highlight the types of signaling crosstalk between TGF-? on the one hand and PAR2/PAR1 on the other hand. Both ligand?receptor systems interact at various levels and by several mechanisms including mutual regulation of ligand?ligand, ligand?receptor, and receptor?receptor at the transcriptional, post-transcriptional, and receptor transactivation levels. These mutual interactions between PAR2/PAR1 and TGF-? signaling components eventually result in feed-forward loops/vicious cycles of matrix deposition and malignant traits that exacerbate fibrosis and oncogenesis, respectively. Given the crucial role of PAR2 and PAR1 in controlling TGF-? receptor activation, signaling, TGF-? synthesis and bioactivation, combining PAR inhibitors with TGF-? blocking agents may turn out to be more efficient than targeting TGF-? alone in alleviating unwanted TGF-?-dependent responses but retaining the beneficial ones. äSignaling Crosstalk of TGF-?/ALK5 and PAR2/PAR1: A Complex Regulatory (epmc).pdf DeepDyve Pubget Overpricing